Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition

Goemaere, Stefan; Ackerman, Christine M.; Goethals, Klara; Keyser, Filip De; Straeten, Catherine Van Der; Verbruggen, Gust; Mielants, Herman; Em, Veys

doi:10.1016/0378-5122(91)90251-k

Cited by 102 publications

(116 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The peak incidence in women coincides with the time of menopause (2), and there is evidence that the female sex hormone estrogen can affect both the incidence and the progression of the disease in humans (3,4) and in animal models (5)(6)(7). The disease activity often decreases during pregnancy (4) and then flares in the postpartum period, when hormone levels drop quickly.…”

mentioning

confidence: 99%

Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis

Jochéms

Islander

Kallkopf

et al. 2007

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. In postmenopausal rheumatoid arthritis (RA), both estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. Hormone replacement therapy (HRT) with estradiol preserves bone mineral density (BMD) and ameliorates arthritis, but long-term therapy is no longer an option due to significant side effects. We therefore used a mouse model of human RA to test the hypothesis that a selective estrogen receptor modulator (SERM), the raloxifene analog LY117018, could be beneficial in the treatment of both arthritis and osteoporosis.Methods. Female DBA/1 mice were ovariectomized and arthritis was induced with collagen immunization. Mice received an injection of raloxifene, estradiol, or vehicle control, administered prophylactically or therapeutically, and thereafter the clinical arthritis score was evaluated continuously. At termination, BMD was analyzed with peripheral quantitative computed tomography. Paws were collected for histology, and sera were analyzed for cytokines and markers of bone and cartilage turnover. Levels of cytokine messenger RNA (mRNA) were investigated with real-time polymerase chain reaction.Results. Treatment with raloxifene dramatically decreased the frequency and severity of arthritis. Effective preservation of bone and cartilage was seen in raloxifene-exposed mice, as demonstrated by increased BMD and decreased serum levels of cartilage oligomeric matrix protein in the raloxifene-treated mice compared with controls. Decreased levels of mRNA for both tumor necrosis factor ␣ and RANKL in spleen cells from raloxifene-treated arthritic mice indicated an immunosuppressive action of this SERM.Conclusion. In a well-established model of postmenopausal RA, the raloxifene analog LY117018 potently inhibits the progression of arthritis and the associated development of osteoporosis, both in a prophylactic and in a therapeutic regimen. Since long-term HRT has been associated with significant side effects, raloxifene may be a useful adjuvant treatment for postmenopausal RA.

show abstract

mentioning

confidence: 99%

Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis

Jochéms

Islander

Kallkopf

et al. 2007

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…4% to 13% 20,21,22,23 . ANA has been reported as 7.6% in Omani population 24 and 4.2% in Saudi Arabian population 20 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Autoantibodies in Healthy Adults in Pakistani Population

Ashraf

Afzal

Kashif

et al. 2016

Bangladesh J Med Sci

View full text Add to dashboard Cite

Introduction: Autoimmune phenomenon is attributed to a number of diseases which were once considered idiopathic. In humans, production of auto antibodies (a-Abs) against self-antigens is quite frequent but earlier their presence was associated with autoimmune diseases, however a-Abs have been documented in non-autoimmune disorders i.e. complicated pregnancy, cancer, stroke etc. In Pakistan, limited data is available on frequency of a-Abs, therefore this study was designed to determine serum level of antinuclear antibody (ANA), Rheumatoid factor (RF) and anti dsDNA antibodies in apparently healthy population. Materials and methods: After written informed consent, blood sample of 256 subjects was obtained by random sampling. Participants of established autoimmune diseases were excluded. Enzyme linked immunosorbent assay (ELISA) was used to determine ANA, RF and anti-dsDNA antibody. Categorical variables were compared by using χ 2 test. A p value <0.05 was considered statistically significant. Results: Rheumatoid factor was the most frequent a-Ab (18%), followed by anti dsDNA (7.4%), while ANA was the lowest (0.4%) antibody detected. Only RF had a statistically significant association with gender (p=0.047). No association of these antibodies with age was detected. Conclusion: Rheumatoid factor auto antibody was more prevalent as compared to ANA and dsDNA antibody in healthy adults.

show abstract

“…This suggests a possible association between estrogen deficiency and disease onset. Female-to-male incidence ratio after age 60 years is approximately 1:1, potentially implicating changes in sex hormones in the development of RA, and a pattern of RA symptom improvement or even remission during pregnancy is well recognized (79)(80)(81). Renal involvement in RA is relatively common and multifactorial and is a predictor of mortality in RA patients.…”

Section: Dialysis and Transplantationmentioning

confidence: 99%

Untitled

2018

Turk Neph Dial Transpl

View full text Add to dashboard Cite

Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly.Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Gender differences continue to exist around the world in access to education, medical care, and participation in clinical studies. Pregnancy is a unique state for women, offering an opportunity for diagnosis of kidney disease, but also a state where acute and chronic kidney diseases may manifest, and which may impact future generations with respect to kidney health. There are various autoimmune and other conditions that are more likely to impact women with profound consequences for child bearing, and on the fetus. Women have different complications on dialysis than men, and are more likely to be donors than recipients of kidney transplants.In this editorial, we focus on what we do and do not know about women, kidney health, and kidney disease, and what we might learn in the future to improve outcomes worldwide. KEY WORDS:Women, Access to care, Kidney health, Acute and chronic kidney disease, Inequities ÖZ Kronik Böbrek Hastalığı dünyadaki erişkin popülasyonun yaklaşık %10'unu etkiler: dünya çapında ölümün en sık görülen 20 nedeninden biridir ve hastalar ile aileleri üzerinde çok ciddi etkileri olabilir. Dünya Böbrek Günü ve Uluslararası Kadınlar Günü 2018 yılında aynı güne denk gelmiştir. Böylece kadın sağlığı ve özellikle böbrek sağlığının toplum ve sonraki nesiller üzerindeki önemini düşünmek, öğrendiklerimizi daha geniş bir şekilde uygulayabilmek için böbrek hastalığının benzersiz yönleri konusunda daha meraklı olmaya çalışmak için bir fırsat sunmaktadır.Dünya nüfusunun yaklaşık %50'sini oluşturan kızlar ve kadınlar toplum ve ailelerine önemli katkılar yaparlar. Dünya çapında eğitime erişim, tıbbi bakım ve klinik çalışmalara katılmada cinsiyetle ilgili farklılıklar bulunmaya devam etmektedir. Hamilelik kadınlar için eşsiz bir dönemdir ve böbrek hastalığına tanı konması fırsatı yaratır ama aynı zamanda böbrek sağlığı açısından gelecek nesilleri etkileyebilecek akut ve kronik böbrek hastalıklarının ortaya çıkabileceği bir durumdur. Kadınları etkilemesi daha olası olan ve çocuk sahibi olma ve fetus üzerinde çok önemli sonuçlar doğurabilecek çeşitli otoimmün ve başka hastalıklar bulunmaktadır. Kadınların diyaliz komplikasyonları erkeklerden farklıdır ve böbrek naklinde alıcı olmak yerine verici olma olasılıkları daha yüksektir.Bu editör yazısında kadınlar, böbrek sağlığı ve böbrek hastalığı hakkında bildiklerimiz ve bilmed...

show abstract

Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition

Cited by 102 publications

References 0 publications

Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis

Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis

Prevalence of Autoantibodies in Healthy Adults in Pakistani Population

Untitled

Contact Info

Product

Resources

About