Onset of puberty in CD-1 mouse pups exposed prenatally through weaning to endophyte-infected tall fescue seed

Varney, D. R.; Varney, L. A.; Hemken, R.W.; Zavos, Panayiotis M.; Siegel, Malcolm R.

doi:10.1016/0093-691x(91)90300-3

Cited by 5 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Female A/J mice have about a 2-year mean life-span [20]; thus, 24 weeks is equivalent to one-fourth of their life-span. In the study reported here, we initiated the experiment at 6 weeks of age, which represents the onset of puberty in mice [21], and continued the study until 30 weeks of age. As such, the experimental period may correspond to adolescence and late middle age in humans.…”

Section: Introductionmentioning

confidence: 99%

Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice

Takeshita

Horiuchi

Izumo

et al. 2011

Environ Health Prev Med

View full text Add to dashboard Cite

Objectives To determine the impact of long-term voluntary exercise, representing habitual exercise for the prevention of lifestyle-related diseases, on glucose, lipid, and amino acid metabolism in mice. Methods Twenty-four mice aged 6 weeks were divided into three groups. Two groups (16 mice) were housed individually in either cages equipped with a running wheel (8 mice, exercising, Ex-mice) or without (8 mice, sedentary, Se-mice) for 24 weeks. The remaining group (8 mice) was sacrificed at 6 weeks of age. Biomarkers related to glucose, lipid, and amino acid metabolism were examined.Results Ex-mice ran voluntarily, predominantly in the dark. The distance per day peaked at 4 weeks and then decreased until 12 weeks to around the level seen at the beginning of the experimental period, and was maintained at 4.9 ± 0.2 km/day from 12 to 24 weeks. Ex-mice showed a similar adrenal weight and vitamin C content to Se-mice but had a significantly lower body weight and higher food intake. Ex-mice also showed a higher skeletal muscle weight, a lower white adipose tissue and liver weight, associated with lower plasma leptin and insulin-like growth factor-1 levels, and a lower hepatic triglyceride content. Analysis of plasma amino acids showed that Ex-mice had significantly higher phenylalanine, tyrosine, and glutamine levels, resulting in a significantly lower Fischer's ratio. Conclusions We present an animal model of long-term voluntary exercise under low stress. Findings related to the effects of long-term voluntary exercise on lipid, and amino acid metabolism in our mouse model indicate that such an exercise regimen may affect pathophysiological states related to appetite and behavior.

show abstract

Section: Introductionmentioning

confidence: 99%

Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice

Takeshita

Horiuchi

Izumo

et al. 2011

Environ Health Prev Med

View full text Add to dashboard Cite

show abstract

“…The negative effect of the endophyte on laboratory rodents has been well‐documented (Zavos et al , ; Varney et al 1991 a , b ; ; Godfrey et al ), although the effect of endophyte consumption on native small mammals is more variable. For instance, Conover () found that meadow voles ( Microtus pennsylvanicus ) preferred non‐infected leaves to infected leaves and it had no effect on reproduction, but when temperature was increased, they exhibited higher mortality.…”

Section: Primary Exotic Grass Speciesmentioning

confidence: 98%

The Impact of 3 exotic, invasive grasses in the Southeastern United States on wildlife

Barnes

Bahm

2013

Wildl. Soc. Bull.

View full text Add to dashboard Cite

Little is known about the impacts and effects of exotic, invasive grasses on wildlife in the Southeast United States. We selected 3 species of exotic grasses common to the Southeast and review the literature on their regional distribution, ecosystem impacts, wildlife impacts, and management. These grasses have the potential to harm indigenous wildlife species, such as northern bobwhite (Colinus virginianus), that need grasslands with a shrub component for nesting, brood-rearing, and loafing. These exotic, invasive grasses are sod-forming in nature, typically forming dense monotypic stands that provide little bare ground and have low plant species and insect diversity. Furthermore, it appears that wildlife do not prefer to consume these plant species. Control is often difficult and usually requires the use of herbicides in combination with mechanical treatment, such as disking, to provide adequate habitat. Attempts should be encouraged to convert these idle grasslands to a mixture of native grasses and forbs to make stands more suitable for wildlife species. We provide suggestions for future research and management needs regarding exotic, invasive grasses and wildlife in the Southeast United States. Ó

show abstract

Are Female Voles Food Limited? Effects of Endophyte-infected Tall Fescue on Home Range Size in Female Prairie Voles (Microtus ochrogaster)

Fortier

Osmon

Roach

et al. 2001

The American Midland Naturalist

View full text Add to dashboard Cite

Onset of puberty in CD-1 mouse pups exposed prenatally through weaning to endophyte-infected tall fescue seed

Cited by 5 publications

References 21 publications

Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice

Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice

The Impact of 3 exotic, invasive grasses in the Southeastern United States on wildlife

Are Female Voles Food Limited? Effects of Endophyte-infected Tall Fescue on Home Range Size in Female Prairie Voles (Microtus ochrogaster)

Contact Info

Product

Resources

About