Onset of late posttraumatic seizure after dehydroepiandrosterone treatment

Karp, Galia; Bentov, Yaakov; Masalha, Rafik; Ifergane, Gal

doi:10.1016/j.fertnstert.2008.08.115

Cited by 16 publications

(11 citation statements)

References 10 publications

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“…DHEA should not be considered as safe because it may result in virilizing side effects, which can be irreversible in some cases [8]. Metabolic and neurologic side effects have been reported as well [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Does dehydroepiandrosterone have any benefit in fertility treatment?

Urman

Yakın

2012

Current Opinion in Obstetrics &Amp; Gynecology

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Section: Introductionmentioning

confidence: 99%

Does dehydroepiandrosterone have any benefit in fertility treatment?

Urman

Yakın

2012

Current Opinion in Obstetrics &Amp; Gynecology

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“…Nevertheless, Gleicher and Barad reported more frequently improved energy levels and better sex drive in patients treated with DHEA [21]. However, one study in literature reported a case of seizure in a patient using DHEA, suggesting need for special attention in women prone to convulsions, although more investigation is needed [22].…”

Section: Side Effectsmentioning

confidence: 99%

Supplimentation with Dehydroepiandrosterone as a Promising Treatment for Poor Responders

Artini¹,

Pinelli²,

Papini³

2012

J Fertiliz In Vitro

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“…Treatment of women to improve ovulation possibilities and IVF chances of pregnancy with DHEA is also popu- (14). Interestingly, Karp et al describes the onset of late posttraumatic seizure after DHEA treatment in an attempt to improve ovarian oocyte production.…”

Section: Dhea-s Testosterone Secretion and Seizuresmentioning

confidence: 99%

Adrenal Androgen Producing Adenoma Associated with Epileptic Seizures

Matulevičius¹

2014

Acta Endo (Buc)

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Background. Dehydroepiandrosterone sulphate (DHEA-S) is a major steroid product of adrenal glands and an important neurosteroid, but due to only slight androgenic activities pathology of DHEA-S secretion it was rarely described until now.Aim. To report a case of DHEA-S and testosterone secreting adrenal tumour with clinical manifestations of suddenly appeared epileptic seizures, amenorrhea, hirsutism, weight gain and decreased sexual activity before operation, and up to 12 months observation after surgical removal of the tumour.Methods. Presentation of clinical case with comments.Results. Epileptic seizures, amenorrhea, weight gain and hirsutism suddenly appeared in a 38-year-old fertile woman. A right adrenal tumour was detected. Blood levels of DHEA-S and testosterone were very high. Surgical removal of the adenoma (confirmed histologically) was performed what conditioned decrease of DHEA-S, testosterone and other hormones in 2-24 hours for the level of adrenal insufficiency. After a month all the hormones returned to normal level and were maintained at this level for 12 months after operation, excepting aldosterone, which increased gradually. Menses reappeared in six weeks after a short period of hot flashes and perspirations. Seizures did not appear in 12 months. Sexual activity was lowered one month before and after the operation, and it was maximal 6-12 months after operation.Conclusions. We report a case with complete recovery of a 38-year-old woman, presented with epileptic seizures, amenorrhea, hirsutism, weight gain and decrease of sexual activity, before and after surgical removal of DHEA-S and testosterone secreting adrenal tumour.

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Onset of late posttraumatic seizure after dehydroepiandrosterone treatment

Cited by 16 publications

References 10 publications

Does dehydroepiandrosterone have any benefit in fertility treatment?

Does dehydroepiandrosterone have any benefit in fertility treatment?

Supplimentation with Dehydroepiandrosterone as a Promising Treatment for Poor Responders

Adrenal Androgen Producing Adenoma Associated with Epileptic Seizures

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