Onset of Coccidioidomycosis in Mouse Lung After Intravenous Injection

Sinski, James T.; Soto, Peter J.; ., Jr.

doi:10.21236/ad0465198

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through the years, a variety of investigators have used murine models to examine pathogenesis and virulence. Early studies demonstrated that after intravenous inoculation of large numbers of arthroconidia, cellular changes occurred very early and that spherules could be observed in the tissues as early as 48 h post infection 17 . Because natural infection is acquired via inhalation, there have been studies done following the temporal progression of pulmonary infection.…”

Section: Studies Of Pathogenesis and Host Responsementioning

confidence: 99%

“…Primary pulmonary infection in either mice or guinea pigs demonstrated that extrapulmonary dissemination appears to occur as early as 7 days post infection 18, 19 . Overall, in numerous studies, in mice and other animal species, the course of infection has been shown to be progressive with increases in the fungal burden in the organs, and increases in organ weight 1,17–26 …”

Section: Studies Of Pathogenesis and Host Responsementioning

confidence: 99%

See 1 more Smart Citation

Experimental Animal Models of Coccidioidomycosis

Clemons¹,

Capilla²,

Stevens³

2007

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Experimental models of coccidioidomycosis performed using various laboratory animals have been, and remain, a critical component of elucidation and understanding of the pathogenesis and host resistance to infection with Coccidioides spp., as well as to development of more efficacious antifungal therapies. The general availability of genetically defined strains, immunological reagents, ease of handling, and costs all contribute to the use of mice as the primary laboratory animal species for models of this disease. Five types of murine models are studied and include primary pulmonary disease, intraperitoneal with dissemination, intravenous infection emulating systemic disease, and intracranial or intrathecal infection emulating meningeal disease. Each of these models has been used to examine various aspects of host resistance, pathogenesis, or antifungal therapy. Other rodent species, such as rat, have been used much less frequently. A rabbit model of meningeal disease, established by intracisternal infection, has proven to model human meningitis well. This model is useful in studies of host response, as well as in therapy studies. A variety of other animal species including dogs, primates, and guinea pigs have been used to study host response and vaccine efficacy. However, cost and increased needs of animal care and husbandry are limitations that influence the use of the larger animal species.

show abstract

Section: Studies Of Pathogenesis and Host Responsementioning

confidence: 99%

Section: Studies Of Pathogenesis and Host Responsementioning

confidence: 99%