Onset of clinical signs in children with HIV-1 perinatal infection

Galli, Luisa; Martino, Maurizio de; Tovo, Pier-Angelo; Gabiano, Clara; Zappa, Marco; Giaquinto, Carlo; Tulisso, S.; Vierucci, A; Guerra, Michele; Marchisio, Paola; Plebani, A; Zuccotti, Gian Vincenzo; Martino, Antonella; Dallacasa, P; Stegagno, M

doi:10.1097/00002030-199509050-00007

Cited by 95 publications

(39 citation statements)

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“…other cohorts. 10,13,18 The most common signs in our cohort were lymphadenopathy, splenomegaly, and hepatomegaly. Although nonspecific, such signs can be useful for making clinical decisions regarding the care of HIV-exposed children (eg, whether to start or continue treatments).…”

Section: Discussionmentioning

confidence: 80%

Survival, Disease Manifestations, and Early Predictors of Disease Progression Among Children With Perinatal Human Immunodeficiency Virus Infection in Thailand

et al. 2002

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ABSTRACT. Objective. To describe survival and signs of human immunodeficiency virus (HIV) infection in perinatally infected children in Thailand.Methods. At 2 large Bangkok hospitals, 295 infants born to HIV-infected mothers were enrolled at birth from November 1992 through September 1994 and followed up with clinical and laboratory evaluations every 1 to 3 months for 18 months. Infected children remained in follow-up thereafter. For the infected children, we used data collected through October 2000 to estimate survival times and compare characteristics among those whose disease progressed at rapid (died within 1 year), intermediate (died at 1-5 years), and slow (survived at least 5 years) rates.Results .

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Section: Discussionmentioning

confidence: 80%

Survival, Disease Manifestations, and Early Predictors of Disease Progression Among Children With Perinatal Human Immunodeficiency Virus Infection in Thailand

et al. 2002

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“…15,16 Recently, the use of highly active antiretroviral therapy has improved life expectancy and the quality of life for these children. 17,18 Progress in the treatment of Aids has changed it into a chronic disease.…”

Section: Resultsmentioning

confidence: 99%

Lack of association between nutritional status and change in clinical category among HIV-infected children in Brazil

et al. 2005

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CONTEXT AND OBJECTIVE: Malnutrition is common among HIV-infected children. Our objective was to study the occurrence of malnutrition and its relationship with changes in clinical category among HIV-infected children. DESIGN AND SETTING: Longitudinal study, at the Pediatrics Department and Pediatrics Investigation Center (CIPED), Faculdade de Ciências Médicas da Universidade Estadual de Campinas (Unicamp). METHODS: We reviewed the hospital records of 127 vertically HIV-infected children. Anthropometric measurements were obtained at the beginning of follow-up, at clinical category change and five months later. These were converted to z-scores of weight/age, height/age and weight/height. Data were presented as means, standard deviations, frequency counts and percentages. The Wilcoxon and Kruskal-Wallis tests and odds ratios were used in the analysis. RESULTS: We found that 51 (40.2%) were undernourished and 40 (31.5%) were stunted, with higher risk of being included in clinical category C. There was an association between nutritional condition and the clinical categories of the Centers for Disease Control classification (1994), and with age at symptom onset (except for height z-score). During follow-up, 36 patients (28.4%) changed their clinical category, which occurred early among the undernourished patients. The group that changed its clinical category maintained the same z-score distribution for weight, height and weight/height throughout follow-up. CONCLUSION: Aids manifestation severity was associated with nutritional status and with age at symptom onset, but change in clinical category was not followed by worsening of nutritional status.

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“…Most presented with symptomatic disease, usually in the form of repeated or opportunistic infections, but signs of organ involvement (such as lymphadenopathy, parotitis, and hepatosplenomegaly) were identified in two thirds of the children. Prospective studies have shown that 80% of vertically infected children show such signs during infancy 5. Wider recognition of these manifestations, together with the awareness that, in London at least, most HIV infected children are of black African origin,3 would probably result in more children being identified before they develop symptoms.…”

Section: Commentmentioning

confidence: 99%