Onset and progression of postmortem histological changes in the central nervous system of RccHan™: WIST rats
Klaus Weber,
Anna Domènech,
Kristel Kegler
et al.
Abstract:Death initiates a cascade of physiological and biochemical alterations in organs and tissues, resulting in microscopic changes that challenge the histopathological evaluation. Moreover, the brain is particularly susceptible to artifacts owing to its unique composition and its location within the cranial vault. The aim of this study was to compile and illustrate the microscopic changes in the central nervous system (CNS) of rats subjected to delayed postmortem fixation. It also scrutinizes the influence of exsa… Show more
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