Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma

Fortune, Brad; Burgoyne, Claude F.; Cull, Grant; Reynaud, Juan; Wang, Lin

doi:10.1167/iovs.13-12219

Cited by 68 publications

(68 citation statements)

References 28 publications

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“…In many cases, such RNFL damages can be observed before a visual field loss is detected [95]. The damage leads to a thinning of the RNFL which is associated with a reduced retardation introduced by this layer to a sampling beam, and it has been shown in animal models that the birefringence is reduced at an even earlier stage of the disease [96]. These findings are the basis for the use of polarimetric techniques for glaucoma diagnosis.…”

Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

333

227

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

333

227

View full text Add to dashboard Cite

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“…Since the RNFL is damaged in glaucoma-the second leading cause of blindness worldwide [132]-and since RNFL birefringence is connected to layer integrity [133,134], the polarization properties of the RNFL were investigated as potential diagnostic markers for glaucoma. PS-OCT based assessment of the RNFL's birefringent properties might be particularly interesting since it was shown that polarization changes in experimental glaucoma can be observed earlier than RNFL thickness changes [135]. Peripapillary RNFL thickness is currently a key OCT parameter for glaucoma diagnostics in state-of-the-art clinical routine [136].…”

Section: Ps-oct In the Eyementioning

confidence: 99%

“…Exemplary PS-OCT fundus images mapping reflectivity and RNFL retardation in a human eye are shown in Figure 5. Also in preclinical research, PS-OCT was used to investigate the birefringence properties of the RNFL and their relation to the intraocular pressure, which is an important parameter for glaucoma, in animals [135,[146][147][148]. Aside from measuring their birefringence, PS-OCT was also demonstrated for tracing nerve fiber bundles in the RNFL [149].…”

Section: Ps-oct In the Eyementioning

confidence: 99%

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Baumann

2017

Applied Sciences

127

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Polarization sensitive optical coherence tomography (PS-OCT) is an imaging technique based on light scattering. PS-OCT performs rapid two-and three-dimensional imaging of transparent and translucent samples with micrometer scale resolution. PS-OCT provides image contrast based on the polarization state of backscattered light and has been applied in many biomedical fields as well as in non-medical fields. Thereby, the polarimetric approach enabled imaging with enhanced contrast compared to standard OCT and the quantitative assessment of sample polarization properties. In this article, the basic methodological principles, the state of the art of PS-OCT technologies, and important applications of the technique are reviewed in a concise yet comprehensive way.

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“…The normal RNFL is birefringent due to the ordered structural array of cytoskeletal proteins within its axons. Fortune and colleagues recently demonstrated that loss of RNFL retardance can occur earlier than RNFL thinning (Fortune et al, 2013a). Forty-one rhesus macaques with experimental glaucoma had longitudinal SDOCT and SLP measurements of cpRNFL thickness and cpRNFL retardance.…”

Section: What Is the Earliest Detectable Change?mentioning

confidence: 99%

Strategies to improve early diagnosis in glaucoma

Tatham¹,

Medeiros²,

Zangwill³

et al. 2015

Progress in Brain Research

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Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, functional abnormalities are detected first. This review describes recent innovations with the potential to improve the early detection of glaucoma. Developments in imaging include novel optic nerve head metrics such as Bruch's membrane opening-minimum rim width, enhanced ability to quantify inner layers of the glaucomatous macula, and ability to image deep optic nerve head structures, including the lamina cribrosa. Developments in detection of early glaucomatous functional loss include novel perimetric tests using frequency-doubling technology and flicker-defined form stimuli. Methods to combine results of structural and functional assessments are also presented that may improve early detection of glaucoma. KeywordsGlaucoma, Optical coherence tomography, OCT, Perimetry, Spectral domain, Early diagnosis Glaucoma is a leading cause of blindness, affecting more than 70 million people worldwide, of whom approximately 10% are bilaterally blind (Quigley and Broman, 2006). Glaucomatous visual losses can be prevented with early diagnosis and treatment; however, affected individuals are typically asymptomatic until later stages of the disease and a large proportion of those affected remain undiagnosed. Population-level surveys suggest only 10-50% of people with glaucoma are aware that they have the condition and consequently there are a large number of people Progress in Brain Research, Volume 221, ISSN 0079-6123, http://dx

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Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma

Abstract: The onset of progressive loss of RNFL retardance occurs earlier than the onset of RNFL thinning. Endpoints of progressive loss from baseline also occurred more frequently and earlier for RNFL retardance as compared with RNFLT.

Cited by 68 publications

References 28 publications

Polarization sensitive optical coherence tomography – a review [Invited]

Polarization sensitive optical coherence tomography – a review [Invited]

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Strategies to improve early diagnosis in glaucoma

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