Onset and progression factors in Parkinson’s disease: A systematic review

Martino, Rosemary; Candundo, Hamilton; Lieshout, Pascal van; Shin, Sabina; Crispo, James A.G.; Barakat-Haddad, Caroline

doi:10.1016/j.neuro.2016.04.003

Cited by 32 publications

(33 citation statements)

References 107 publications

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“…Lack of association with tobacco smoking, a potential confounder in our analysis, does not raise concerns about the quality of data. Smoking has been associated with PD risk in some, but not all reports; most evidence comes from studies of males and reduction in risk appears to occur predominantly among heavy smokers (>30 pack years), who were rare in our sample with the highest exposure group greater than or equal to 20 pack years. As such, our analysis is among the most informative regarding the impact of occupation among US women and risk of PD.…”

Section: Discussionmentioning

confidence: 67%

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Occupation and Parkinson disease in the Women's Health Initiative Observational Study

Burstyn

LaCroix

Litvan

et al. 2019

American J Industrial Med

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Introduction There is a lack of consistent study findings on associations between workplace exposures and the risk of Parkinson disease (PD) and a paucity of such data on women. We assessed PD risk among occupational groups to derive insights about potential occupation‐specific exposures in a large cohort of women. Methods The Women's Health Initiative Observational Study (WHI‐OS) is a prospective cohort that enrolled 91 627 postmenopausal women, 50 to 79 years of age, from 01 October 1993 through 31 December 1998, at 40 clinical centers across the United States, with average follow‐up interval of 11 years. These women reported up to three paid jobs, held the longest since age 18; these jobs were coded and duration of employment calculated. We defined a case by self‐report of doctor‐diagnosed PD (at baseline or follow‐up), death attributed to PD, or taking medication consistent with PD. Results Among 2590 PD cases, we found evidence of excess risk among “counselors, social workers, and other community and social service specialists,” and there was a suggestion of increased in risk among postsecondary teachers, and “building and grounds cleaning and maintenance” workers. There was also evidence of a deficit in risk among women who worked in sales. Results according to ever‐employed and job duration were similar, except for evidence of excess risk among “health technologists and technicians” with more than 20 years of employment. Longer duration of life on a farm was associated with higher risk. Conclusion Our findings paint a largely reassuring picture of occupational risks for PD among US women.

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Section: Discussionmentioning

confidence: 67%

“…There is epidemiologic evidence that some occupational exposures are etiologically related to Parkinson disease (PD), as well as some genetic and lifestyle factors . There is consistent supportive evidence of PD risk associated with exposure to manganese and some pesticides.…”

Section: Introductionmentioning

confidence: 99%

Occupation and Parkinson disease in the Women's Health Initiative Observational Study

Burstyn

LaCroix

Litvan

et al. 2019

American J Industrial Med

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“…Experiments designed to assess the consequences of long-term exposures to PCBs and related environmental organohalogens on aging-related neuropathology present unique set of challenges. Aging-related declines in cognitive capacity, clinical dementia, and the major neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS) have both genetic and environmental components that contribute to temporal onset, progression and severity [69,122,199]. Gene by environment interactions have also been implicated in several neurodevelopmental disorders [70,113,176].…”

Section: Discussionmentioning

confidence: 99%

Neurotoxicity of polychlorinated biphenyls and related organohalogens

et al. 2019

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Halogenated organic compounds are pervasive in natural and built environments. Despite restrictions on the production of many of these compounds in most parts of the world through the Stockholm Convention on Persistent Organic Pollutants (POPs), many "legacy" compounds, including polychlorinated biphenyls (PCBs), are routinely detected in human tissues where they continue to pose significant health risks to highly exposed and susceptible populations. A major concern is developmental neurotoxicity, although impacts on neurodegenerative outcomes have also been noted. Here, we review human studies of prenatal and adult exposures to PCBs and describe the state of knowledge regarding outcomes across domains related to cognition (e.g., IQ, language, memory, learning), attention, behavioral regulation and executive function, and social behavior, including traits related to attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). We also review current understanding of molecular mechanisms underpinning these associations, with a focus on dopaminergic neurotransmission, thyroid hormone disruption, calcium dyshomeostasis, and oxidative stress. Finally, we briefly consider contemporary sources of organohalogens that may pose human health risks via mechanisms of neurotoxicity common to those ascribed to PCBs.

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“…Based on the findings and advanced methods, the study on the association between other kinds of pesticides and PD would increase in the future. Secondly, it is widely accepted that PD is induced by the combination of various factors, and the projects on a single sort of factor have reached a certain amount (14,(63)(64)(65). In the future, it is believed that the combined effect such as pesticides and genes, different kinds of pesticides, and pesticides and lifestyle will attract increasing attention.…”

Section: Discussionmentioning

confidence: 99%

A Scientometric Analysis and Visualization of Research on Parkinson's Disease Associated With Pesticide Exposure

Liu

Zhang

et al. 2020

Front. Public Health

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The etiology and pathogenesis of Parkinson's disease (PD) have not yet been clearly described. Both genetic and environmental factors contribute to the onset and progression of PD. Some pesticides have been demonstrated to be associated with PD by many previous studies and experiments, and an increasing number of researchers have paid attention to this area in recent years. This paper aims to explore the knowledge structure, analyze the current research hot spots, and discuss the research trend through screening and summarizing the present literature. Based on 1767 articles from the Web of Science Core Collection and PubMed database, this study carried out the analysis from the keywords, cited references, countries, authors, and some other aspects by using Citespace. The hot topics, valuable articles, and productive authors in this research field could be found after that. To the best of our knowledge, this is the first study to specifically visualize the relationship between pesticide exposure and PD, and forecast research tendency in the future.

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Onset and progression factors in Parkinson’s disease: A systematic review

Cited by 32 publications

References 107 publications

Occupation and Parkinson disease in the Women's Health Initiative Observational Study

Occupation and Parkinson disease in the Women's Health Initiative Observational Study

Neurotoxicity of polychlorinated biphenyls and related organohalogens

A Scientometric Analysis and Visualization of Research on Parkinson's Disease Associated With Pesticide Exposure

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