Onosma L.: A review of phytochemistry and ethnopharmacology

Kumar, Neeraj; Kumar, R. Nirmal; Kishore, Kamal

doi:10.4103/0973-7847.120513

Cited by 74 publications

(77 citation statements)

References 29 publications

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“…The naturally occurring flora is the largest and striking resource of novel drugs. A. napellus is a medicinal plant extensively used for the management of sciatica and rheumatic algesia [34,35]. Aconite is recognized as a valuable natural product for countering the symptoms of diabetic neuropathy e.g., sensation, cold and algesia [36].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Dried Tubers of Aconitum napellus

Shoaib

Siddiqui

Dixit

et al. 2020

Plants

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The present study was designed to explore the neuroprotective properties of Aconitum napellus (Ranunculaceae). The plant detoxification was done using either water, or cow or goat milk as per the Ayurvedic shodhana method. The evaluation of the neuroprotective role of A. napellus was performed on diabetic neuropathy induced by streptozotocin in Sprague Dawley (SD) rats. Body mass, blood sugar level, oral glucose tolerance test, hyperalgesia, cold allodynia, motor co-ordination test, and locomotor activity, oxidative biomarkers (TBARS, reduced glutathione, catalase and superoxide dismutase) and sciatic nerve histomorphology were assessed. The in vitro studies were done on human neuroblastoma cell line SHSY-5Y and used an MTT assay to assess the antiproliferative activity of different extracts. Results suggest that the goat milk treated chloroform extract has less percentage of aconitine. After administration of the detoxified chloroform extract to the diabetic animals, there was a significant improvement in the myelination and degenerative changes of the nerve fibers along with behavioral changes (p < 0.05 as compared with diabetic control group). The findings of the in vitro research show an effective neuroprotective role of A. napellus. This suggests that A. napellus should be further investigated for its effect in diabetic pathology.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Dried Tubers of Aconitum napellus

Shoaib

Siddiqui

Dixit

et al. 2020

Plants

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“…In folk medicine, Boraginaceae species have been used for the treatment and prevention of many ailments and diseases such as hypertension, diarrhea and diabetes mellitus and have been a tremendous resource for the development of new drugs [28][29][30][31] . Many species of Boraginaceae family are grown in Iran and some of them are used in ethnomedicine [4] .…”

Section: Resultsmentioning

confidence: 99%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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Faezizadeh, et al.: Antiglycation Effects of Some Boraginaceae SpeciesNon-enzymatic glycation of proteins is the major cause of diabetic complications and therefore, inhibition of this reaction could reduce the morbidity of this disease. The aim of this study was to evaluate the in vitro effects of aqueous and hydroethanol extracts of Echium italicum L., Anchusa arvensis L. and Trichodesma incanum (Bunge) A. DC. of Boraginaceae on albumin, hemoglobin, and crystalline glycation reaction. The results showed that the hydroethanol extract of Echium italicum in the concentrations of 100, 50 and 10 mg/dl could reduce the rate of albumin glycation to 85.10±1.85, 64.14±1.12 and 40.13±1.17%, respectively, and also in the same conditions, rates of hemoglobin glycation were reduced to 69.20±1.71, 46.13±1.93 and 27.73±0.90%, respectively. Moreover, extracts of three tested plants have antiglycation effects on crystalline glycation reaction. Under the identical conditions, the inhibitory effects of hydroethanol extracts of Echium italicum on the albumin, hemoglobin, and crystalline glycation reaction were higher than other extracts. The findings showed that the extracts of tested species, particularly in the hydroethanol form, could be used to prevent and treat complications of diabetes mellitus. Key words: Echium italicum L., Anchusa arvensis L., Trichodesma incanum (Bunge) A. DC., albumin, hemoglobin, glycationMembers of the family Boraginaceae include herbs, shrubs and trees totaling about 146 genera and 2000 species in the worldwide [1] . Some of these plants grow in Iran and used widely in Iran's folk medicine [2,3] . It has been reported that Borage (Borago officinalis L.) was useful for its antipyretic, antihypertensive, antispasmodic, aphrodisiac and diuretic properties [4,5] . Previous findings showed that some species of Boraginaceae were used for the treatment of hemorrhoids [6] . Furthermore, it has also been observed that various parts of Echium species could be used for their antiinflammatory, antibacterial, antidepressant, antiproliferative, antiviral, antioxidant, cytotoxic and anxiolytic properties [2,3] . Cyanidin, a natural phenolic compound is present in many kinds of plants, such as grapes, pomegranate and some species of Boraginaceae and according to the previous reports, this effective compound has antioxidant and antidiabetic potential [7][8][9][10] .Diabetes mellitus is a common endocrine disease and a leading cause of morbidity and mortality in the world [11] . In this disease, the macro and microvascular complications lead to severe effects on the eyes, central nervous systems and kidneys [12] . Evidence from in vitro and in vivo experiments indicated that diabetic hyperglycemia could increase the risk of complications [13,14] . It seems that non-enzymatic glycation plays an important role in progression of diabetic complications [11] . Due to prolonged hyperglycemia, the non-enzymatic glycation of proteins could significantly change their structural and functional properties [12] . Previous studie...

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“…We highlight that the 2 phytochemicals, Onosmone and Truxillic acid, that have no similarity with any of the FDA approved drugs are among the isolated nodes in the similarity network ( Figure 5B). Based on plant-phytochemical associations in our database, Onosmone and Truxillic acid are phytochemical constituents of Indian medicinal plants, Onosma echioides and Erythroxylum coca, respectively, and a survey of the literature shows that these phytochemicals are under active investigation for their therapeutic uses [84][85][86][87][88] . We also highlight that none of the 14 mostdruggable phytochemicals are captured by Phytochemica 20 database while 6 of the 14 phytochemicals are captured by Nutrichem 18,19 database.…”

Section: Chemical Similarity Network Of the Most-druggable Phytochemimentioning

confidence: 99%