Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

Abstract

. (2016) 'Online quantitative mass spectrometry for the rapid adaptive optimisation of automated ow reactors.', Reaction chemistry engineering., 1 (1). pp. 96-100.Further information on publisher's website:Publisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

Online Monitoring of Polymerizations: Current Status

“…Bourne and coworkers reported an automated continuous reactor for the synthesis of organic compounds which uses online mass spectrometry for reaction monitoring and product quantification. [75] Ley and coworkers developed a miniature electrospray ionization mass spectrometer coupled to a preparative flow chemistry system by making use of a switching valve in between.…”

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

“…They were able to gather multistep kinetic information about a nucleophilic aromatic substitution (Scheme 15A) [117] and showed self-optimization of different reactions with their systems (Scheme 15B and C). [118] …”

The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds

“…7,72,73 Several different analytical systems were used successfully, such as in-line FT-IR (predominantly with Attenuated Total Reflectance (ATR) cells), [74][75][76][77][78][79][80] NIR, 81,82 Raman 83 and NMR spectroscopy, 84,85 as well as on-line MS 86,87 and HPLC. 88,89 However, everyday application of these approaches is hindered by the fact that off-line solutions are usually more convenient, since a wider toolbox (consisting of existing equipment) is available for the analysis of less demanding analytes (i.e.…”

“…78,[87][88][89][92][93][94] Realization of production scale API synthesis cannot be imagined without strict control of processes and final product quality. 25 These efforts are exemplified by the production of Artemisinin related APIs, where monitoring of the reaction stream after a photochemical transformation could reveal an eventual lamp failure.…”