2018
DOI: 10.1039/c8lc00456k
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Abstract: The demand for real-time monitoring of cell functions and cell conditions has dramatically increased with the emergence of organ-on-a-chip (OOC) systems. However, the incorporation of co-cultures and microfluidic channels in OOC systems increases their biological complexity and therefore makes the analysis and monitoring of analytical parameters inside the device more difficult. In this work, we present an approach to integrate multiple sensors in an extremely thin, porous and delicate membrane inside a liver-… Show more

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Cited by 101 publications
(95 citation statements)
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“…Photonic curing after thermal sintering at 130 • C yields structures that feature about 10% of the conductivity of bulk gold, which is a 60-fold higher conductivity than previously reported structures on cyclic olefin polymer [16] that were sintered in Ar plasma for 30 min. On other substrates, like polyethylene naphthalate (PEN) or SU-8 covered polytetrafluoroethylene (PTFE) conductivities of a comparable order of magnitude were achieved by thermal sintering at 150 • C [17] and 130 • C [37], respectively. However, the latter sources report the necessity of performing an electrochemical activation step prior to use.…”
Section: Discussionmentioning
confidence: 99%
“…Photonic curing after thermal sintering at 130 • C yields structures that feature about 10% of the conductivity of bulk gold, which is a 60-fold higher conductivity than previously reported structures on cyclic olefin polymer [16] that were sintered in Ar plasma for 30 min. On other substrates, like polyethylene naphthalate (PEN) or SU-8 covered polytetrafluoroethylene (PTFE) conductivities of a comparable order of magnitude were achieved by thermal sintering at 150 • C [17] and 130 • C [37], respectively. However, the latter sources report the necessity of performing an electrochemical activation step prior to use.…”
Section: Discussionmentioning
confidence: 99%
“…Another advantage of an organ-on-a-chip is that it can achieve real-time monitoring by integrating with sensors. As shown in Figure 4b, Moya et al used an inkjet-printed oxygen sensor with a liver-on-a-chip to evaluate metabolic activity in real-time [82].…”
Section: Liver Chips Based On Layer-by-layer Depositionmentioning
confidence: 99%
“…(b) Schematic, cross-section, and real image of an oxygen sensor-integrated liver chip. Reproduced with permission from[82].…”
mentioning
confidence: 99%
“…Based on those works, the oxygen gradient in a flow chamber was correlated with the CYP450 gradient in rat hepatocytes . In addition, few examples of devices have integrated oxygen biosensors in the liver culture chamber to couple biological and mass transport/mechanical phenomena . In this view, we have proposed a technology in which an oxygen sensor layer containing platinium (II) octaethylporphyrin (PtOEP) was embedded at the bottom of a liver‐on‐chip device .…”
Section: Introductionmentioning
confidence: 99%
“…20,21 In addition, few examples of devices have integrated oxygen biosensors in the liver culture chamber to couple biological and mass transport/mechanical phenomena. [22][23][24] In this view, we have proposed a technology in which an oxygen sensor layer containing platinium (II) octaethylporphyrin (PtOEP) was embedded at the bottom of a liver-on-chip device. 25 The originality of our sensor allowed a 2D mapping of the oxygen profile and oxygen concentration over a large area (about 1 cm 2 ).…”
Section: Introductionmentioning
confidence: 99%