Online oxygen measurements inside a microreactor with modeling of transport phenomena

Evaluation of Diffusion Coefficient Determination using a Microfluidic Device

“…This was also confirmed by our report, where a very good agreement between experimental data 23 More than that, the on-line validation of developed macroscopic mathematical models, ranging from a full 3D description of transport phenomena, incorporating convection, diffusion and reaction terms along with the parabolic velocity profile confirmed that the simplified less precise models assess the required model complexity for achieving precise results and to depict the governing transport characteristics at the microscale. 24 It was shown that for the majority of microfluidic studies involving forced convection, modeling can be done without considering diffusion in the direction of convection, which is in accordance with calculated Péclet numbers. Likewise, although 2D simulations assumed an infinitely deep channel, they produced identical solutions as the 3D model.…”

Advanced characterization of immobilized enzymes as heterogeneous biocatalysts

“…Reactions may take place in the continuous phase or at the surface of the microchannel walls. Internal sensing along the microchannel wall(s) therefore constitutes a highly promising element of process monitoring and control in microreactors [203,[206][207][208][209].…”

Recent advances and future applications of microfluidic live-cell microarrays

“…(Hata, Kichise, 2003. A variety of integrated optical luminescence sensors to improve on-chip optical cell analysis (Schapper et al, 2009) have been reported recently using single-point measurements (Lam et al, 2009) and two-dimensional readout systems (Nock et al, 2008a, b, Sud et al, 2006, Thomas et al, 2011, Ungerbock et al, 2013b. For instance, Ungerboek et al implemented a two-wavelength ratiometric imaging system (Ungerbock et al, 2013a) to combine low-cost and readily available optical equipment (fluorescent microscopes) with highresolution imaging for oxygen sensing in cell-based microfluidic systems.…”