Online Noninvasive Localization of Accessory Pathways in the EP Lab

Abstract

Abstract. Inverse electrocardiography has been developing during the last years and is about to become a valuable clinical tool for analyzing arrhythmias and electrical dysfunction in general. By combining measurements obtained by electrocardiographic body surface mapping with three-dimensional anatomical data, the electrical activation sequence of the individual human heart can be imaged noninvasively. This technique was applied on-line in the electrophysiology lab. The results of four patients, who underwent an interventional electrophysiology study, are presented in this paper. The sites of early activation were compared to the locations of successful radio-frequency ablation. The location error was found to be between 13 and 20 mm. This promising finding may bring this noninvasive method closer to clinical application.

Noninvasive Imaging of Cardiac Electrophysiology (NICE)

“…Geometrial regularization is achieved by a 2 nd order Tikhonov regularization applying the surface Laplacian. Studies confirmed that NICE can be applied in a clinical environment for solving electrophysiologically relevant problems (Berger T. et al, 2006;2011;Modre R. et al, 2004;2003;Seger M. et al, 2004;., Hanser F., Modre-Osprian R., Fischer G., Messnarz B., Berger T., Hintringer F., Pachinger O. & Roithinger F. X., 2002).…”

“…Selected publications reflecting the related development and progress of this method are (Berger T. et al, 2006;2011;Fischer G. et al, 2000;1999;Modre R. et al, 2006;2003;Pfeifer B. et al, 2008;Renhardt M. et al, 1992;Seger M. et al, 2004;Tilg B., Hanser F., Modre-Osprian R., Fischer G., Messnarz B., Berger T., Hintringer F., Pachinger O. & Roithinger F. X., 2002;Tilg B. et al, 1992;Wach P. et al, 2001;1997).…”