Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media

Juenemann, Daniel; Bohets, Hugo; Ozdemir, Mahir; Maesschalck, Roy De; Vanhoutte, Koen; Peeters, Karl; Nagels, L.J.; Dressman, Jennifer B.

doi:10.1016/j.ejpb.2010.12.014

Cited by 29 publications

(21 citation statements)

References 20 publications

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“…Due to the addition of either milk or infant formula, fedstate gastric media exists as a complex multiphase system (23). Proteins within the media deter direct filtration of samples through 0.45 μm filters.…”

Section: Solubility Experimentsmentioning

confidence: 99%

Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

2015

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Section: Solubility Experimentsmentioning

confidence: 99%

Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

2015

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“… FaSSGF, fasted‐state simulated gastric fluid; FaSSIF‐V2, updated fasted‐state simulated intestinal fluid; [56] FaSSIF, fasted‐state simulated intestinal fluid. …”

Section: Analytical Techniques To Measure the Dissolution Rate Of Nanmentioning

confidence: 99%

Analytical methods for dissolution testing of nanosized drugs

Jünemann

Dressman

2012

Journal of Pharmacy and Pharmacology

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“…The electrode can be ‘programmed’ for a charged compound. A recent study used such a versatile ion‐selective electrode for drug dissolution in biorelevant media with diphenhydramine hydrochloride as a model [124]. USP 2 apparatus was selected, and the potentiometric data were compared with a HPLC‐UV analysis as a reference.…”

Section: Real‐time Analysis Of Small‐scale Drug Dissolution and Precimentioning

confidence: 99%

“…A recent study used such a versatile ion-selective electrode for drug dissolution in biorelevant media with diphenhydramine hydrochloride as a model. [124] USP 2 apparatus was selected, and the potentiometric data were compared with a HPLC-UV analysis as a reference. The reference analytics were generally in good agreement with the potentiometric ion sensor.…”

Section: Further Real-time Analytical Techniques For Small-scale Dissmentioning

confidence: 99%

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

Kuentz

2014

Journal of Pharmacy and Pharmacology

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Objectives This review focuses on real-time analytics of drug dissolution and precipitation testing on a comparatively small scale. Key findings Miniaturisation of test equipment is an important trend in pharmaceutics, and several small-scale experiments have been reported for drug dissolution and precipitation testing. Such tests typically employ analytics in realtime. Fibre optic ultraviolet (UV) analytics has become a well-established method in this field. Novel imaging techniques are emerging that use visible or UV light; also promising is Fourier transform infrared imaging based on attenuated total reflection. More information than just a rate constant is obtained from these methods. The early phase of a dissolution process can be assessed and drug precipitation may eventually be observed. Some real-time techniques are particularly well suited to studying drug precipitation during formulation dispersion; for example, turbidity, focused beam reflectance measurement and Raman spectroscopy. Summary Small-scale dissolution tests equipped with real-time analytics have become important to screen drug candidates as well as to study prototype formulations in early development. Future approaches are likely to combine different analytical techniques including imaging. Miniaturisation started with mini-vessels or small vials and future assays of dissolution research will probably more often reach the level of parallel well plates and microfluidic channels.

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Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media

Cited by 29 publications

References 20 publications

Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

Analytical methods for dissolution testing of nanosized drugs

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

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