Online hyphenation of in-capillary aptamer-functionalized solid-phase microextraction and extraction nanoelectrospray ionization for miniature mass spectrometry analysis

Abstract

Direct mass spectrometry (MS) analysis is vital to chemical and biological investigations. However, measuring complex samples is challenging due to matrix interference, resulting in compromised MS performance. In this study,...

Online highly selective recognition of domoic acid by an aptamer@MOFs affinity monolithic column coupled with HPLC for shellfish safety monitoring

“…[30][31][32] The selective IT-SPME of the massive amount of aptamers on the affinity monolith offers an attractive opportunity for the online selective capture and precise measurement of various analytes. 33 This sheds light on a promising approach for the online accurate recognition of DA. So far, aptamer-based affinity materials have received much attention, while online selective IT-SPME for the accurate analysis of DA based on affinity monoliths is still absent.…”