Online hyphenated liquid chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry for drug metabolite and nature product analysis

Yang, Zheng

doi:10.1016/j.jpba.2005.10.002

Cited by 66 publications

(51 citation statements)

References 63 publications

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“…The miniaturized system using micro-NMR probe increased the sensitivity of the instrument, enabling the detection of metabolites with limited quantity in medium to low complexity matrices without the need for SPE concentration. The experimental design of LC/NMR/MS and the recent advances in this technology, such as improvement in the probe design, are discussed elsewhere [78,79,[83][84][85]. These same approaches are applicable in identifying unknown metabolites of pharmaceuticals in the environment.…”

Section: Challenges In Metabolite Identification In the Environmentmentioning

confidence: 99%

Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks

Celiz

Tso

Aga

2009

Enviro Toxic and Chemistry

290

149

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Abstract-The occurrence of human and veterinary pharmaceuticals in the environment has been a subject of concern for the past decade because many of these emerging contaminants have been shown to persist in soil and water. Although recent studies indicate that pharmaceutical contaminants can pose long-term ecological risks, many of the investigations regarding risk assessment have only considered the ecotoxicity of the parent drug, with very little attention given to the potential contributions that metabolites may have. The scarcity of available environmental data on the human metabolites excreted into the environment or the microbial metabolites formed during environmental biodegradation of pharmaceutical residues can be attributed to the difficulty in analyzing trace amounts of previously unknown compounds in complex sample matrices. However, with the advent of highly sensitive and powerful analytical instrumentations that have become available commercially, it is likely that an increased number of pharmaceutical metabolites will be identified and included in environmental risk assessment. The present study will present a critical review of available literature on pharmaceutical metabolites, primarily focusing on their analysis and toxicological significance. It is also intended to provide an overview on the recent advances in analytical tools and strategies to facilitate metabolite identification in environmental samples. This review aims to provide insight on what future directions might be taken to help scientists in this challenging task of enhancing the available data on the fate, behavior, and ecotoxicity of pharmaceutical metabolites in the environment.

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Section: Challenges In Metabolite Identification In the Environmentmentioning

confidence: 99%

Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks

Celiz

Tso

Aga

2009

Enviro Toxic and Chemistry

290

149

View full text Add to dashboard Cite

show abstract

“…this technique applicable to metabolomics studies (Dunn et al 2005). Additionally, the advent of new NMR probe techniques, particularly the introduction of cryoprobes , has resulted in electronic noise reduction and up to a fourfold increase in sensitivity (Yang 2006).…”

Section: Nuclear Magnetic Resonancementioning

confidence: 99%

Biomarkers for NeuroAIDS: The Widening Scope of Metabolomics

Pendyala¹,

Want²,

Webb³

et al. 2006

Jrnl Neuroimmune Pharm

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"Metabolomics", the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and several unique characteristics. The current applications for this field are, primarily, toxicological profiling and biomarker studies. This review of metabolomics research highlights the identification of reliable biomarkers with emphasis on neuroAIDS. Such identification of candidate markers will be advantageous for tracking the progression of human immunodeficiency virus/central nervous system (HIV/CNS) disease to gain maximal benefit from antiretroviral treatment and to provide insight into the mechanism of related neuropathogenesis.

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“…More detailed introduction about LC -NMR is available from books and review articles. 80,81 The Key Concerns of LC -NMR…”

Section: General Introduction To Lc -Nmrmentioning

confidence: 99%

Identification and Structure Elucidation of Compounds from Herbal Medicines

Liang

Jin

Feng

et al. 2010

Traditional Herbal Medicine Research Methods

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Online hyphenated liquid chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry for drug metabolite and nature product analysis

Cited by 66 publications

References 63 publications

Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks

Pharmaceutical metabolites in the environment: Analytical challenges and ecological risks

Biomarkers for NeuroAIDS: The Widening Scope of Metabolomics

Identification and Structure Elucidation of Compounds from Herbal Medicines

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