Renewable energy sources (RES) are grooming especially when we need a clean and green energy. It will reduce the dependency on fossil fuels and also reduces the environmental pollution. To improve efficiency in power system numerous techniques and optimization algorithms are available. But with each one some limitations and its complexities are there because they are time consuming due to heavy computation burden, large number of iterations, need heavy computation and slow convergence. So, a proficient method is required for tackling this issue. Therefore, we need to implement an efficient technique for solving this problem. This paper presents the inverter control strategy using Artificial neural network for grid assembled photovoltaic system. The three-phase inverter have been simulated by using ANN technique to mitigate the problems of voltage instability, harmonics distortion in case of constant irradiance, variable irradiance and faulty condition also. The obtained output in the proposed system reduces the harmonics to a large extent and it will also eliminate the power quality issues by inoculating the real or reactive power with no or very less distortions than the one in traditional system.