Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails

Yuan, Xi; Shen, Jie; Chen, Li; Wang, Liang; Yan, Qing; Zhang, Jiaping

doi:10.1111/iwj.13542

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…A previous meta-analysis studied the effects of onion extract on healing, finding that onion gel increases adverse effects and has no benefit; however, onion extract in silicone gel generates improvements in healing and could be the optimal solution. Accordingly, the scientific evidence for silicone gel with herbal extracts for surgical scar enhancement is very scarce, and further research is needed to determine appropriate parameters such as doses and dosages that generate maximum benefit without harmful effects [44].…”

Section: Discussionmentioning

confidence: 99%

Treatment and Improvement of Healing after Surgical Intervention

Bueno,

Nevado-Sanchez,

Pardo-Hernández

et al. 2023

Healthcare

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The development of abnormal scars has a great impact on people’s well-being, and improving scarring outcomes after surgery is a field that currently lacks consensus. This review aims to identify newly researched approaches to improving the quality of surgical scars. A systematic search of PubMed, Scopus, Web of Science, and ScienceDirect was conducted between 13 May 2023 and 17 May 2023, in accordance with the recommendations of the PRISMA Statement. Study selection and analysis of methodological quality were performed in parts, independently and blindly, based on eligibility criteria. The 21 prospective, comparative, and randomized studies reviewed included 1057 subjects and studied approaches such as topical applications of creams with herbal extracts and silicone gels, growth factors, negative pressure dressings, oligonucleotides, intralesional injection of compounds such as botulinum toxin, skin closure techniques such as suturing and tissue adhesive, and laser treatments. There are recent research techniques that generate good results and are really promising to improve the results of surgical scars; however, the available evidence is extremely limited in some cases, and it is necessary to deepen its analysis to obtain reliable action protocols in each type of surgery.

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Section: Discussionmentioning

confidence: 99%

Treatment and Improvement of Healing after Surgical Intervention

Bueno,

Nevado-Sanchez,

Pardo-Hernández

et al. 2023

Healthcare

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“…In metaanalysis study, onion extract was found to be effective in scar hyperpigmentation (Ruan et al, 2019). In another meta-analysis study, although onion extract gel increases the total improvement of scar assessment, no difference was found between onion extract gel and other topical treatments (Yuan et al, 2021).…”

Section: Onion (Allium Cepa L Family Amaryllidaceae)mentioning

confidence: 98%

Plants with cosmetic uses

Mansoor,

Aburjai,

Al‐Mamoori

et al. 2023

Phytotherapy Research

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The use of plants as a source of active principles for cosmetics has significantly increased in the last few years. Safety, compatibility with all types of skin, fewer side effects, and availability are among the advantages of herbal cosmetics above synthetic ingredients. The present review aims to explore the most important plants used in cosmetics. A literature search was carried out in several electronic databases with the following phrases: skincare and plants; cosmetics and plants; natural and cosmetics; and natural and skincare. Furthermore, more detailed filters such as clinical studies, meta‐analyses, and systemic reviews were applied to positive results. Various plants and plant extracts currently used in skin care, scaring, whitening, and aging, as well as in sun protection, acne, eczema, and others, have been included in this review. The effectiveness of these plants is based mainly on preclinical research, and to a lesser extent on clinical studies. Some plant extracts or oils have been tested clinically, such as onions, aloe, and tea tree oil, more than other plant extracts. Despite many studies on natural products to improve dermal needs, proper clinical cosmeceutical trials are much fewer than expected. Therefore, more clinical trials are needed to evaluate appropriate efficacy. Furthermore, new formulation technologies might enhance the cosmeceutical benefits, but more work is warranted.

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“…Contractubex™ consists of a mixture of Extractum capea, heparin, sodium, and allantoin. It has entered the standard treatment guidelines for the hypertrophic scars and keloids [ 9 ]. The anti-inflammatory and anti-fibrotic efficacy of this combination in epidural fibrosis and intra-abdominal adhesion models were examined and promising results were obtained [ 10 , 11 ].…”

Section: Highlight Key Pointsmentioning

confidence: 99%

Effect of Extractum Cepae, Heparin Sodium and Allantoin Combination (Contractubex) on Adhesion and Fibrosis After Neck Surgery (Thyroidectomy) in Rats

Balas¹

2021

North Clin Istanbul

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OBJECTIVE Reoperative thyroid surgery is technically difficult process with increased complications due to the adhesions and fibrosis caused by the previous surgery. In this experimental animal model, we planned to investigate the effect of Contracttubex TM , a mixture of Extractum cepae, Heparin sodium and Allantoin, on adhesion and fibrosis after neck surgery (thyroidectomy). METHODS The current study is an experimental animal model of post-thyroidectomy adhesion. Twelve Wistar-Albino male rats in two groups were used. Under sterile conditions, a midline incision on the neck was made. The anterior thyroid muscles were separated and the thyroid lodge was reached. As a minor interventional procedure, a sponge was applied to the thyroid tissue, and then a combination of 1 g Extractum capae, heparin, sodium, and allantoin was applied to the dissection site in the drug group. Rats in both groups were sacrificed on 30 th day. Cervical regions were dissected and evaluated for macroscopic adhesion. Tissue samples were taken for microscopic evaluation for fibrosis and inflammation. RESULTS In the experimental group in which Contractubex TM was applied, inflammation was not detected in five (83.3%) of six rats while no inflammation was detected in four (66.7%) of six rats in the control group (p=0.505). Considering the fibrosis score, mild or moderate fibrosis was detected in four (66.7%) of six rats in the control group, while fibrosis was found in only two (33.3%) rats in the experimental group (p=0.264). When macroscopic adhesion was evaluated, two (33.3%) rats of the control group subjects were Grade 4, and one (16.7%) was Grade 3. No rats in the experimental group were Grade 4 (p=0.392). CONCLUSION Contractubex TM seems to be effective in preventing adhesions and fibrosis after thyroidectomy and neck surgery, but further research is needed for use in human studies.

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Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails

Cited by 8 publications

References 18 publications

Treatment and Improvement of Healing after Surgical Intervention

Treatment and Improvement of Healing after Surgical Intervention

Plants with cosmetic uses

Effect of Extractum Cepae, Heparin Sodium and Allantoin Combination (Contractubex) on Adhesion and Fibrosis After Neck Surgery (Thyroidectomy) in Rats

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