2011
DOI: 10.2337/db09-1368
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Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

Abstract: OBJECTIVEβ-Cell turnover and its potential to permit β-cell regeneration in adult primates are unknown. Our aims were 1) to measure β-cell turnover in adult nonhuman primates; 2) to establish the relative contribution of β-cell replication and formation of new β-cells from other precursors (defined thus as β-cell neogenesis); and 3) to establish whether there is an adaptive increase in β-cell formation (attempted regeneration) in streptozotocin (STZ)-induced diabetes in adult nonhuman primates.RESEARCH DESIGN … Show more

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Cited by 38 publications
(32 citation statements)
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“…Aging is thought to be associated with reduced capacity to regenerate b-cells, as suggested by studies involving rodents (13)(14)(15) and humans (16)(17)(18). On the one hand, for example, the b-cell toxin streptozotocin, partial pancreatectomy, or exendin-4 were more effective in stimulating b-cell proliferation in younger mice (younger than 12 months old) than in older mice (13)(14)(15)19). On the other hand, the age-associated decline in b-cell function in older rats has been shown to be reversible with glucagonlike peptide 1 (GLP-1; exendin) treatment (20), suggesting stimulation of b-cell regeneration (21).…”
Section: Effects Of Agingmentioning
confidence: 99%
“…Aging is thought to be associated with reduced capacity to regenerate b-cells, as suggested by studies involving rodents (13)(14)(15) and humans (16)(17)(18). On the one hand, for example, the b-cell toxin streptozotocin, partial pancreatectomy, or exendin-4 were more effective in stimulating b-cell proliferation in younger mice (younger than 12 months old) than in older mice (13)(14)(15)19). On the other hand, the age-associated decline in b-cell function in older rats has been shown to be reversible with glucagonlike peptide 1 (GLP-1; exendin) treatment (20), suggesting stimulation of b-cell regeneration (21).…”
Section: Effects Of Agingmentioning
confidence: 99%
“…Regeneration of β cells may be similarly restricted in non-human primates. Butler and colleagues recently investigated the β cell regenerative capacity of middle-aged velvet monkeys in response to streptozotocin (40). Although streptozotocin reliably induced diabetes, β cell replication was not increased in the monkeys.…”
Section: Aging Impairs Human β Cell Functionmentioning
confidence: 99%
“…These cells, located within the islets of Langerhans, display a slow turnover rate (3,4). Conditions such as pregnancy and obesity are associated with a diminished sensitivity of insulin target tissues and a consequent rise in the insulin demand that is compensated for by an increase in the number and secretory activity of β cells (2,(5)(6)(7).…”
Section: Introductionmentioning
confidence: 99%