Ongoing Development and First Long-Term Trials of a Cardiac Output Monitoring System in the Pulmonary Artery (Compass)

Pfennig, Michael; Cleven, Nina J.; Biela, Sara; Urbaszek, A.; Ooyen, A. van; Görtz, Michael; Mokwa, W.; Schmitz‐Rode, Thomas

doi:10.1515/bmt-2013-4220

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“…The pressure sensor probe was implanted in an acute setting in an anesthetized Rhoen sheep using a specially developed minimally invasive implantation technique [3]. For reference, two 2-channel pressure transducer catheters (SP 780C, Millar Instruments, Houston, Texas) were introduced for simultaneous continuous measurement of left ventricular pressure (LVP), aortic pressure (AoP), right ventricular pressure (RVP) and pulmonary artery pressure (PAP).…”

Section: Methodsmentioning

confidence: 99%

Hemodynamic Monitoring with an Implantable Pressure Monitor is Improved by Additional Detection of Heart Sounds

Urbaszek

Kirchner

Ooyen

et al. 2012

Biomedical Engineering / Biomedizinische Technik

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Early diagnosis of cardiac decompensation is essential to improve therapy of heart failure as one of the most costintensive chronic diseases worldwide. This can be achieved by remote monitoring of pulmonary artery pressure. An implantable pressure sensor system is developed in a joint research project (COMPASS), funded by the BMBF. The application of pulse contour analysis, which is well established for stroke volume estimation based on aortic blood pressure, to pulmonary artery pressure (PAP) is challenging due to different signal morphology and limited signal resolution. Especially the incisure in the pressure signal which marks valve closure is often not visible. Therefore, it was investigated whether valve closure can be detected by additional use of heart sounds more reliably. Blood pressure of an anesthetized Rhoen sheep was measured in the pulmonary artery with the implantable pressure monitor COMPASS and, for reference, additionally with commercial pressure catheters (Millar Instruments) in the pulmonary artery, aorta, left and right ventricles. Heart sounds were detected with a 3D accelerometer fixed at the animal's chest. For reference, valve opening and closure were derived from left ventricular pressure. With PAP only, 6.3% of all cardiac cycles were unusable for PCA at low and medium heart rates, as either valve opening or closure were missed or not correctly identified. At very high heart rates the loss rate increased up to 87%. When both PAP and accelerometer data were used, the loss rate was reduced to 0.1% … 0.4% for all heart rates. Combining blood pressure analysis with heart sounds improves the detection of valve opening and closure and thus SV estimation, especially at high heart rates.

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Section: Methodsmentioning

confidence: 99%