“…According with the anti-apoptotic, anti-oxidative and anti-inflammatory effects of this TF, we observed its increased expression following NF-induced neuronal apoptotic rescue ( Figure 1 and Figure 3 ) [ 43 ]. From a clinical point of view, Twist2 is upregulated in a variety of cancers, including glioma and neuroblastoma [ 181 ]. In addition, Twist2 dysfunctions are associated with human pathological conditions characterized by oxidative stress-induced neuronal death, supporting its potential role as therapeutical target for cancer and neurological diseases [ 199 , 200 , 200 , 201 , 202 , 203 ].…”