One year treatment of Barrett<b>’</b>s oesophagus with proton pump inhibitors (a multi-center study)

Babić, Žarko; Bogdanović, Zoran; Dorosulić, Zdravko; Petrović, Zrnka Kovačić; Kujundžić, Milan; Banić, Marko; Marušić, Marinko; Heinzl, Renata; Bilić, Branko; Andabak, Matej

doi:10.1080/17843286.2015.1107203

Cited by 1 publication

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“…Two RCTs ( online supplemental table 3 ) were included in the review 19 20 to address the efficacy of proton pump inhibitors (PPIs) and aspirin for chemoprevention. Both the studies included people with low-grade dysplasia in Barrett’s oesophagus.…”

Section: Consultationmentioning

confidence: 99%

National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma

di Pietro,

Trudgill,

Vasileiou

et al. 2024

Gut

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Barrett’s oesophagus is the only known precursor to oesophageal adenocarcinoma, a cancer with very poor prognosis. The main risk factors for Barrett’s oesophagus are a history of gastro-oesophageal acid reflux symptoms and obesity. Men, smokers and those with a family history are also at increased risk. Progression from Barrett’s oesophagus to cancer occurs via an intermediate stage, known as dysplasia. However, dysplasia and early cancer usually develop without any clinical signs, often in individuals whose symptoms are well controlled by acid suppressant medications; therefore, endoscopic surveillance is recommended to allow for early diagnosis and timely clinical intervention. Individuals with Barrett’s oesophagus need to be fully informed about the implications of this diagnosis and the benefits and risks of monitoring strategies. Pharmacological treatments are recommended for control of symptoms, but not for chemoprevention. Dysplasia and stage 1 oesophageal adenocarcinoma have excellent prognoses, since they can be cured with endoscopic or surgical therapies. Endoscopic resection is the most accurate staging technique for early Barrett’s-related oesophageal adenocarcinoma. Endoscopic ablation is effective and indicated to eradicate Barrett’s oesophagus in patients with dysplasia. Future research should focus on improved accuracy for dysplasia detection via new technologies and providing more robust evidence to support pathways for follow-up and treatment.

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Section: Consultationmentioning

confidence: 99%

National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma

di Pietro,

Trudgill,

Vasileiou

et al. 2024

Gut

View full text Add to dashboard Cite

show abstract

One year treatment of Barrett’s oesophagus with proton pump inhibitors (a multi-center study)

Abstract: Regeneration of the squamous epithel was the same for all PPIs but not good enough to stop the progression of the disease.

Cited by 1 publication

References 29 publications

National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma

National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma

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