One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Kikuchi, Shinji; Murakami, Keiko; Obara, Taku; Ishikuro, Mami; Ueno, Fumihiko; Noda, Aoi; Onuma, Takehide; Kobayashi, Natsuko; Sugawara, Junichi; Yamamoto, Masayuki; Yaegashi, Nobuo; Kuriyama, Shinichi; Tomita, Hiroaki

doi:10.1016/j.jad.2021.08.118

Cited by 17 publications

(21 citation statements)

References 38 publications

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“…However, despite the similarities in both the origin and maternal comorbidities of these disorders, women affected by PreE and HELLP syndrome have both reported feelings of post-partum depression or anxiety, but at different levels; an effect mirrored in the current study [ 58 ]. There have been several clinical studies reporting the onset of post-partum depression/anxiety occurring as early as in the first 3 months among 11.1–19.2% of women and by 1-year post-partum in 6.2–13.1% of women [ 59 , 60 , 61 ]. With this wide range of time for symptom onset, it is possible that we did not evaluate the correct time frame.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension

Wallace

Bowles

Griffin

et al. 2022

Behavioral Sciences

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Background: Hypertensive disorders of pregnancy, such as Preeclampsia (PreE) and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome, affects approximately 5–10% of pregnancies and increases the risk of women developing disorders, such as anxiety or depression, in the postpartum period. Using preclinical rodent models, we set out to determine whether rats with a history of PreE or HELLP had evidence of anxiety, depression or cognitive impairment and whether immune suppression during pregnancy prevented these changes in mood and/or cognition. Methods: Timed-pregnant rats were infused with sFlt-1 and/or sEng to induce PreE or HELLP beginning on gestational day 12. After delivery, a battery of validated behavioral assays was used to assess post-partum depression, anxiety and learning. Results: There was no negative effect on maternal pup interaction due to PreE or HELLP; however, hypertensive dams spent more time immobile in the forced swim test (p < 0.0001). Hypertensive dams also spent less time in the open area of the open field (p = 0.001). There were no significant changes in recognition memory (p = 0.08); however, spatial learning was impaired in hypertensive dams (p = 0.003). Immobility time in the forced swim test was positively correlated with increased circulating S100B (p = 0.04), while increased time spent in the outer zones of the open field was negatively correlated with BDNF levels (p < 0.0001). Conclusion: The results from this study suggest that hypertensive pregnancy disorders are associated with depression, anxiety and learning impairments in the post-partum period.

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Section: Discussionmentioning

confidence: 99%

Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension

Wallace

Bowles

Griffin

et al. 2022

Behavioral Sciences

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“…Screening for psychological distress is also important to identify mothers who should be intervened with. Assessment of maternal mental health in the one-month postpartum period is widely conducted in Japan [ 45 ]. On the other hand, we propose focusing more on assessing maternal mental health during pregnancy and providing psychosocial support for mothers with psychological distress during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

et al. 2022

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Background Childcare facilities are a factor that lowers the established association of mother’s postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. Methods The present study was based on the data from 23,130 mother–child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½–5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. Results The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. Conclusions Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.

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“…We de ned K6 ≥ 5 points as psychological distress in this study. This value has been shown to maximize the sum of sensitivity and speci city in screening for mood and anxiety disorders in the Japanese version of K6 and has also been used in the previous study [23,24]. Furthermore, we classi ed mother and child pairs based on psychological distress into four categories: no psychological distress in both prenatal and postnatal periods (none), only the prenatal period (prenatal only), only the postnatal period (postnatal only), and both the prenatal and postnatal periods (both).…”

Section: Maternal Psychological Distressmentioning

confidence: 99%

Association of Maternal Psychological Distress and Use of Childcare Facilities with Children's Behavior Problems: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Takahashi

Murakami

Kobayashi

et al. 2022

Preprint

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Background Childcare facilities have been reported as a factor in lowering the association of postnatal psychiatric symptoms with children's behavior problems; however, no studies have considered prenatal psychiatric symptoms. This study aimed to examine whether the use of childcare facilities moderates the association of maternal psychological distress in the prenatal and postnatal periods with behavior problems in children. Methods The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We used the K6 to assess and divide maternal psychological distress in early pregnancy and two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavior problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) at four years of age. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavior problems. To examine whether the use of childcare facilities moderates the association between maternal psychological distress and children's behavior problems, we conducted a stratified analysis based on the use of childcare facilities or not at two years old. In addition, the interaction term between maternal psychological distress and the use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for interaction. Results The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavior problems was significant, except a significant association was not identified between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities. In addition, interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. Conclusions The use of childcare facilities did not moderate the association of maternal psychological distress in prenatal and postnatal periods with behavior problems in children.

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One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Cited by 17 publications

References 38 publications

Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension

Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension

Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Association of Maternal Psychological Distress and Use of Childcare Facilities with Children's Behavior Problems: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

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