One-year Survival Rate of Patients with Primary Malignant Central Nervous System Tumors after Surgery in Kazakhstan

Akshulakov, Serik; Igissinov, Nurbek; Aldiyarova, Nurgul; Akhmetzhanova, Zauresh; Ryskeldiyev, Nurzhan; Auezova, Raushan; Zhukov, Yevgeniy

doi:10.7314/apjcp.2014.15.16.6973

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Review studies of cancer incidence in Central Asia are of particular interest as the cancer incidence depends on a variety of factors including medical, geographical, and social living conditions, the nature and specificity of employment, and ethnic characteristics (Moore et al, 2010;Moore et al, 2011). The natural climatic conditions and industrial development of Kazakhstan, as well as the socio-economic conditions of living and ethnic structure of the population determine the specificity and peculiarities of cancer pathology (Igissinov et al, 2011;2013a;2013b;2014;Bilyalova et al, 2012;Akshulakov et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Cancer Incidence and Mortality Data in Aktobe, West Kazakhstan, 2000-2010

Bekmukhambetov

Imangazina²,

Jarkenov³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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The article provides an assessment of the dynamics of cancer incidence and mortality in the territory of Aktobe city for the period 2000-2010. The most common cancers were found in the lungs, stomach, esophagus and breast throughout the period, with slight increase in colon cancer and decrease in esophageal cancer being apparent. In an attempt to cast light on effects of environmental pollution, the authors also compared data on total emissions of chemicals into the air. While preliminary, the findings provide a basic picture of cancer burden in this industrialised city in Kazakhstan which should be followed up by more comprehensive monitoring.

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Section: Introductionmentioning

confidence: 99%

Cancer Incidence and Mortality Data in Aktobe, West Kazakhstan, 2000-2010

Bekmukhambetov

Imangazina²,

Jarkenov³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The 1-, 3-, 5-, and 10-year survival rates for malignant gliomas were estimated at 63.4%, 46.2%, 39.4%, and 34.8% in South Korea [ 10 ], while the 2-year survival for Swedish people that were diagnosed with high-grade glioma was 19,5% [ 11 ]. According to the previous study, the 1-year survival for patients with malignant CNS tumors in Kazakhstan was 56.5% overall, 79.5% for lower grades, and 33.1% for grades 3 and 4 [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Current State of Adult Glial Tumor Patients’ Care in Kazakhstan: Challenges in Diagnosis and Patterns in Survival Outcomes

Babi¹,

Menlibayeva²,

Bex³

et al. 2023

Biomedicines

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Background: The study aimed to analyze the 5-year survival of adult patients with glial tumors and to define characteristics that are associated with the disease outcomes in Kazakhstan. Methods: Medical records of patients that were surgically treated at the National Center for Neurosurgery during the 5-year period from 2016 to 2020 were collected retrospectively. Patients with a histologically confirmed diagnosis of diffuse astrocytic or oligodendroglial tumor type were included and their survival was assessed with life tables, Kaplan–Meier plot, and Cox regression using STATA 16 statistical software. Results: Almost half of the patients had glioblastoma. The 5-year survival rate of the whole sample was 45.93%. Among Grade 4 patients, 15.6% survived the 5-year mark. Differences in survival between grades 1–3 were not significant. Grade 1 patients demonstrated worse survival rates compared to Grade 2 patients (69% vs. 74%). Worse survival rates were observed among patients of Russian ethnicity and in rural residents. Conclusions: The study described the unusual patterns in survival rates of glial tumor patients in Kazakhstan, pointing to the need for reassessment of diagnostic accuracy and resulting treatment of glial patients in Kazakhstan, and the need to introduce molecular and genetic parameters in tumor type classification. Moreover, the observed difference in survival of different ethnic groups and residents of rural and urban areas should be further investigated and addressed by healthcare professionals.

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“…Incidence in women is 22.3 and for men 18.8 per 100,000 populations. According to the international data, the rates of 5-year survival in malignant brain tumors vary considerably depending on the histological subtype and 79.1% for oligodendrogliomas, 27.4% for anaplastic astrocytomas and 4.5% for glioblastomas (Ohgaki et al, 2005;Akshulakov et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Compared with lung cancer or breast cancer it is relatively uncommon malignant tumor, but nevertheless, due to its aggressive nature and direct CNS affect it has disproportionately greater percentage of morbidity and mortality with serious influence on the healthcare system in general, and especially on the patients themselves, their families and loved ones (Tuleutayev, 2012). Also one of the important factors is that the clinical manifestations of this tumor are varied and can appear actually suddenly in the setting of the overall health, and they are accompanied by severe neurological deficits caused by compression of the brain tissue, often with seizures, focal symptoms, can cause a stroke, causing deep anxious-depressive disorders, which significantly reduce quality of life of patients (Ohgaki et al, 2005;Akshulakov et al, 2014). The initial stages of the disease may also present psychiatric symptoms which assigned to 7 main categories, such as depressive symptoms, apathy, manic symptoms, psychosis, personality changes, eating disorders, and a miscellaneous category for the less frequently encountered symptoms (Madhusoodanan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Introduction of Questionnaires for Quality of Life of Patients with Malignant Tumors of the Central Nervous System into Neurosurgical Practice in the Republic of Kazakhstan

Akshulakov¹,

Aldiyarova²,

Ryskeldiyev³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Studies of quality of life (QoL) of oncological patients is carried out using questionnaires approved in many international clinical studies. The European Organization for Research and Treatment of Cancer EORTC QLQ-C30 (Quality of Life Questionnary-Core 30) and its special brain cancer module EORTC QLQ-BN20 are widely used in the world neurooncologic practice. They are available in more than 80 official versions of 30 languages of the world. Previously we used the official versions in Russian, which often causes difficulty in understanding for native Kazakh language speakers, who comprise more than 60% of our respondents. This was the reason for creating a version of Kazakh language. Therefore, in 2014 for the first time the process of adaptation of questionnaires to the Kazakh language was initiated. Materials and Methods: The translation process of questionnaires to Kazakh language was held in accordance with the requirements of the European Organization for Research and Treatment of Cancer EORTC on QoL and consisted of the following stages: preparation -translation -pilot testing -approval. The official permission of authors and "Guideline on translation" was obtained which was developed by the working group of the EORTC on QoL. The pilot testing of EORTC QLQ-C30 and QLQ-BN20 questionnaires was conducted on the basis of the Department of Central Nervous System Pathology of the "National Centre for Neurosurgery" in patients with malignant tumors of the central nervous system. Results: The official versions of the EORTC QLQ-C30 and QLQ-BN20 questionnaires in Kazakh language were introduced and adapted in practical neurosurgical operations in Kazakhstan. Conclusions: The approved versions of the questionnaires in Kazakh language are now available for mainstream use on the official website EORTC.com. The versions of these questionnaires can be used in domestic cohort studies and clinical practice in the Republic of Kazakhstan. The use of these tools for assessing QoL will help professionals in the planning of individual treatment strategies and selection of the necessary therapy.

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One-year Survival Rate of Patients with Primary Malignant Central Nervous System Tumors after Surgery in Kazakhstan

Cited by 4 publications

References 21 publications

Cancer Incidence and Mortality Data in Aktobe, West Kazakhstan, 2000-2010

Cancer Incidence and Mortality Data in Aktobe, West Kazakhstan, 2000-2010

The Current State of Adult Glial Tumor Patients’ Care in Kazakhstan: Challenges in Diagnosis and Patterns in Survival Outcomes

Introduction of Questionnaires for Quality of Life of Patients with Malignant Tumors of the Central Nervous System into Neurosurgical Practice in the Republic of Kazakhstan

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