One‐year quality of life and functional outcomes of transoral robotic surgery for carcinoma of unknown primary

Abstract

Patients reported difficulties with eating and social disruption over the course of 1 year, but problems with speech and appearance abated.

Transoral robotic surgery (TORS) using the da Vinci Xi: prospective analysis of feasibility, safety, and outcomes

“…In line with our EORTC QLQ‐H&N35 findings, TORS‐CRT patients had lower QOL scores on HNCI until POM 6. However, compared to our population, TORS‐CRT patients in the study by Sethia already had significantly lower baseline QOL scores 29 . Taken together, it seems that adjuvant treatment after TORS, especially CRT, significantly reduces long‐term function and QOL, so strict patient selection (excluding cN+ patients with possible extracapsular extension) and complete resection with free margins are critical 28,30 .…”

Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta‐analysis

“…Literature search identified 1035 studies (Figure ); after scrutinizing titles and abstracts, 1003 were excluded as non‐relevant, concerning other diseases, duplicates, non‐original studies, or non‐English studies. Forty‐two articles, which included palatine tonsillectomy in the diagnostic approach of SCCUP, were screened in full‐text: 4 studies were from the same institution, more precisely 2 from the University of Florida College of Medicine and 1 from The Johns Hopkins Hospital, and another 1 from the University of Pittsburgh Medical Center, which subsequently published 3 updated series included in the review; 4 studies contained non‐SCC histopathology; 6 studies have not reported enough information about the negativity of the physical examination and/or conventional cross‐sectional imaging carried out before tonsillectomy; 3 studies using TLM as surgical approach to the palatine tonsil were lacking data on the state of conventional imaging before EUA or on tonsillectomies performed; 7 studies did not specify the number of tonsillectomies performed; 2 studies had suspicious findings on physical examination and/or conventional cross‐sectional imaging carried out before TORS tonsillectomy; 1 was an anatomopathological study without any clinical information on patients involved; and 1 study conducted palatine tonsillectomy before conventional imaging. Excluded studies and respective reasons of exclusion are summarized in Table .…”

Human Papillomavirus and Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region: A Comprehensive Review on Clinical Implications

“…One ongoing study from Canada is pursuing the successful identification of SCCUP with TORS among T0, N1-N3, and M0 patients and possible de-intensified adjuvant RT therapy (NCT03281499) but could be limited by its small sample size ( n = 22) and recruitment not limited by HPV status, yet similar designs should be implemented as a research purpose at multiple institutions. TORS has been proven as a safe procedure with limited effect on QoL [ 34 , 113 , 114 ]; however, one of the primary reasons for unplanned readmission following TORS is pain [ 115 ]. This is being investigated in an ongoing Danish national randomized clinical trial assigning patients to either a high-dose or low-dose dexamethasone treatment regime following TORS (NCT04189107) [ 116 ].…”