One-Year Outcomes of Diabetic Versus Nondiabetic Patients With Non–Q-Wave Acute Myocardial Infarction Treated With Percutaneous Transluminal Coronary Angioplasty

Gowda, Manohar S.; Vacek, James L.; Hallas, Dave

doi:10.1016/s0002-9149(98)00117-9

Cited by 24 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding is consistent with previous studies that primarily used a conservative management strategy for UA/NSTEMI [7,8,9,10,11]. Nevertheless, as our major novel finding we were able to attribute most of this excess risk to two factors: more advanced coronary artery disease and more severe UA/NSTEMI at presentation.…”

Section: Discussionsupporting

confidence: 91%

“…The number of adults with diabetes mellitus worldwide is likely to grow from 135 million in 1995 to approximately 300 million in 2025 [6]. However, only limited information is available regarding the outcome of diabetic patients after hospital admission with unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI), the most common reason for admission to a coronary care unit [7,8,9,10,11]. The OASIS registry prospectively collected data from UA/NSTEMI patients treated with predominately medical therapy in six different countries including the United States, and reported that diabetes mellitus independently predicted mortality [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of diabetes mellitus on long-term outcome after unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy

et al. 2004

View full text Add to dashboard Cite

Aims/hypothesis. We sought to evaluate the impact of diabetes mellitus on long-term outcome in patients with unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy. Methods. We carried out a prospective cohort study in 270 diabetic and 1163 non-diabetic patients with unstable angina and non-ST-segment elevation myocardial infarction. All patients underwent coronary angiography and, if appropriate, subsequent revascularisation within 24 hours of admission. The primary endpoint was allcause mortality during follow-up for up to 60 months. Results. Diabetic patients had less favourable baseline characteristics including more advanced coronary artery disease and more severe unstable angina and non-ST-segment elevation myocardial infarction. Percutaneous coronary intervention was performed in 53% of diabetic patients and 56% of non-diabetic patients. Coronary artery bypass grafting was done in 21% of diabetic patients and 12% of non-diabetic patients. In-hospital mortality (4.1% vs 1.3%; hazard ratio 3.47; 95% CI: 1.57 to 7.64; p=0.002) and long-term mortality (9.7% vs 4.9%; hazard ratio 2.11; 95% CI: 1.33 to 3.36; p=0.002) were significantly higher in diabetic patients. After adjustment for differences in baseline characteristics, diabetes mellitus was no longer an independent predictor of long-term mortality (hazard ratio 1.43; 95% CI: 0.74 to 2.78; p=0.292). Conclusions/interpretation. Diabetic patients treated with a very early invasive strategy for unstable angina and non-ST-segment elevation myocardial infarction have a higher in-hospital and long-term mortality that is largely explained by their less favourable baseline characteristics including more advanced coronary artery disease and more severe unstable angina and non-ST-segment elevation myocardial infarction.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impact of diabetes mellitus on long-term outcome after unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy

et al. 2004

View full text Add to dashboard Cite

show abstract

“…5,6) However, AMI patients with DM still have a poor prognosis. [1][2][3] They are frequently susceptible to poor prognostic conditions such as reinfarction, 10) the need for target vessel revascularization (TVR), 11) and heart failure. 12,13) Furthermore, there have been several reports on the relationship between DM and cardiac death in AMI patients, [1][2][3]14) while on the other hand, some researchers have reported conflicting results with respect to whether the presence of DM becomes a predictor of mortality in AMI.…”

Section: Discussionmentioning

confidence: 99%

“…12,13) Furthermore, there have been several reports on the relationship between DM and cardiac death in AMI patients, [1][2][3]14) while on the other hand, some researchers have reported conflicting results with respect to whether the presence of DM becomes a predictor of mortality in AMI. 11,15) Yet, it is still unclear whether there is a clear relationship between DM and cardiac mortality in AMI patients.…”

Section: Discussionmentioning

confidence: 99%

<b>Clinical Outcomes and Left Ventricular Function in Diabetic Patients With Acute Myocardial Infarction Treated by Primary Coronary Angioplasty</b>

et al. 2005

View full text Add to dashboard Cite

SUMMARYThe objective of the present study was to compare left ventricular (LV) function and clinical outcomes in diabetics versus nondiabetics with acute myocardial infarction (AMI) treated by primary coronary angioplasty.A total of 327 consecutive AMI subjects were reperfused by primary coronary angioplasty within 12 hours from onset. Diabetes mellitus (DM) was present in 104 of the 327 patients. LV function was serially determined by left ventriculograms taken in the acute and chronic phases (6 months after onset). (I) The early ST-segment resolution rate was lower in DM patients compared with non-DM patients (59% versus 83%, P < 0.0001). (II) During a 6-month follow-up, the percentages of target vessel revascularization (TVR), coronary aorta bypass grafting (CABG), and cardiac death were higher in the DM patients compared with the non-DM patients (TVR: 29% versus 19%; P < 0.05, CABG: 10% versus 5% ; P < 0.05, cardiac death: 12% versus 4%; P = 0.01). (III) The differences in left ventricular ejection fraction (LVEF) between two stages (delta-LVEF) were significantly lower in the DM patients than the non-DM patients (1 ± 9% versus 7 ± 10%, P < 0.0001).(IV) Multivariate analysis identified DM as an independent predictor of cardiac death (Odds ratio 5.5, 95% CI, 1.3-23.7, P < 0.05) and as a sole independent predictor of LVEF deterioration (Odds ratio 5.8, 95% CI, 2.8-11.8, P < 0.001).In patients with AMI treated using primary coronary angioplasty, DM is closely related to left-ventricular systolic dysfunction and a poor patient outcome, including mortality. (Int Heart J 2005; 46: 607-618)

show abstract

“…Neben akuten ischämischen Komplikationen weisen Patienten mit höhergradigen Koronarstenosen (> 70%) häufig limitierende Angina pectoris auf. Die perkutane transluminale Koronarangioplastie (PTCA) hat sich als ein Standardverfahren in der Behandlung von Patienten mit koronarer Ein-und Mehrgefäßerkrankung etabliert [4,5,11]. Die primäre Erfolgsrate dieses Verfahrens beträgt 90 bis 95% [12,19], wobei mit schweren Komplikationen bei elektiven Interventionen in unter 3% der Fälle [6] und bei Risikopatienten in 5 bis 10% der Fälle zu rechnen ist [7].…”

unclassified

Ergebnisse einer Befragung von 549 Patienten zum klinischen Langzeitverlauf und zur Lebensqualität vier Jahre nach PTCA

Schröder

Baumbach²,

Herdeg³

et al. 2000

Med Klin

View full text Add to dashboard Cite

show abstract

One-Year Outcomes of Diabetic Versus Nondiabetic Patients With Non–Q-Wave Acute Myocardial Infarction Treated With Percutaneous Transluminal Coronary Angioplasty

Cited by 24 publications

References 25 publications

Impact of diabetes mellitus on long-term outcome after unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy

Impact of diabetes mellitus on long-term outcome after unstable angina and non-ST-segment elevation myocardial infarction treated with a very early invasive strategy

<b>Clinical Outcomes and Left Ventricular Function in Diabetic Patients With Acute Myocardial Infarction Treated by Primary Coronary Angioplasty</b>

Ergebnisse einer Befragung von 549 Patienten zum klinischen Langzeitverlauf und zur Lebensqualität vier Jahre nach PTCA

Contact Info

Product

Resources

About