One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms

Almufarrij, Ibrahim; Munro, Kevin J.

doi:10.1080/14992027.2021.1896793

Cited by 113 publications

(155 citation statements)

References 92 publications

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“…From 17 included studies, the estimated prevalence was 8% (CI: 5 to 13%). This is between the prevalence rates reported by Almufarrij and Munro [10] of 14.8% (CI: 6.3 to 26.1) and Jafari et al [11] of 4.5% (CI: 1.2 to 15.3). All three reviews included different studies due to different protocols followed but provide some insights into the possible expected prevalence from the published literature.…”

Section: The Effect Of Contracting Covid-19 On Tinnitussupporting

confidence: 45%

“…Due to the different types of study designs included in this review, quality assessment for the included studies was assessed using the National Institute of Health Quality Assessment Tools [53]. Although other tools are available, using the same tool as used in similar systematic reviews (e.g., Almufarrij and Munro [10]) allowed for consistency. Specifically, the Quality Assessment Tool for Case-Control Studies, for Observational Cohort and Cross-Sectional Studies, and for Before-After (Pre-Post) Studies with No Control Group were used depending on the study design.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…The first, by Almufarrij et al [7], was published from searches in May 2020, followed by one by Saniasiaya [8] and Maharaj et al [9] regarding searches in July 2020. A systematic review undertaken in December 2020 investigating audio-vestibular symptoms following contracting COVID-19 indicated that tinnitus had an estimated prevalence of 14.8% (CI: 6.3 to 26.1) from 12 studies [10]. Other audio-vestibular symptoms were less prevalent, such as hearing loss (7.6%; CI: 2.5-15.1) and vertigo (7.2%; CI: 0.01-26.4).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of COVID-19 and the Pandemic on Tinnitus: A Systematic Review

Beukes

Ulep

Eubank

et al. 2021

JCM

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This review aimed to systematically review what has been published regarding tinnitus during the coronavirus disease 2019 (COVID-19) pandemic up to March 2021 by performing both narrative and quantitative meta-analyses. Of the 181 records identified, 33 met the inclusion criteria, which generally had a fair risk of overall bias. In the included, 28 studies focused on the impact of the COVID-19 virus on tinnitus and 5 studies focused on the impact of the pandemic on tinnitus. From the studies identifying the impact of COVID-19 on tinnitus, there were 17 cross-sectional studies (n = 8913) and 11 case series or case report studies (n = 35). There were 2 cross-sectional studies (n = 3232) and 3 pre-post-test design studies (n = 326) focusing on the impact of the pandemic on tinnitus. No consistent patterns were found regarding the presentation of the tinnitus or additional factors that could have tinnitus developing in the disease impact studies. For the pandemic impact studies, the associated stress and anxiety of the pandemic were consistently suggested to contribute to tinnitus experiences. The pooled estimated prevalence of tinnitus post COVID-19 was 8% (CI: 5 to 13%). Medical professionals should be aware that tinnitus might be more problematic following the pandemic or after having COVID-19.

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Section: The Effect Of Contracting Covid-19 On Tinnitussupporting

confidence: 45%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of COVID-19 and the Pandemic on Tinnitus: A Systematic Review

Beukes

Ulep

Eubank

et al. 2021

JCM

View full text Add to dashboard Cite

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“…Furthermore, in some of the reported cases the absence of audiological examination prior to the onset of the acute hearing loss, is another possible drawback since it is not possible to compare pre and post hearing threshold levels. This aspect has been discussed by other Authors 41,42,43,44 ; in some of the reported cases, it is not clear if the symptoms represent the worsening of a pre-existing disease triggered by SARS-CoV-2, or a clinical manifestation entirely related to the virus, or a coincidental event.…”

Section: Discussionmentioning

confidence: 91%

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Fancello

Hatzopoulos

Corazzi

et al. 2021

Int J Immunopathol Pharmacol

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To describe the audio-vestibular disorders related to the newly SARS-CoV-2 infection, including the possible ototoxicity side-effects related to the use of drugs included in the SARS-CoV-2 treatment protocols. A systematic review was performed according to the PRISMA protocol. The Medline and Embase databases were searched from March 1, 2020 to April 9, 2021. Initially the search yielded 400 manuscripts, which were reduced to 15, upon the application of inclusion criteria. Sensorineural hearing loss (SNHL) is the most frequent audio-vestibular symptom described, occurring alone or in association with tinnitus and vertigo. The etiopathogenesis of the inner ear disorders related to COVID-19 infection is still poorly understood. The number of reports of COVID-19 infections associated to audio-vestibular disorders is increasing; even if the quality of the studies available is often insufficient, audio-vestibular disorders should be considered as possible manifestations to be included among the symptoms of this infection.

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“…In conclusion, given our reported experience, the recent report by MHRA and the preliminary data on tinnitus and SNHL caused by Sars-CoV-2 infection (Almufarrij and Munro 2021), large-scale well-designed studies are needed to improve surveillance of the COVID-19 vaccine, to clearly establish if tinnitus is an adverse effect and better define possible adverse reactions involving the cochleo-vestibular system.…”

Section: Discussionmentioning

confidence: 93%

Tinnitus following COVID-19 vaccination: report of three cases

Parrino

Frosolini

Gallo

et al. 2021

International Journal of Audiology

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Objective: To ensure the safety and quality of vaccines, especially the newest RNA-vaccines against COVID-19, is one of the World Health Organization's current highest priorities. Design: Case description. Study sample: We report three cases of sudden unilateral tinnitus following BNT162b2 mRNA-vaccine injection, which rapidly resolved in 2 out of 3 cases. Results: The mechanism responsible for its development remains unclear. A hypersensitivity reaction with an abnormal autoimmune response or a vasculitic event may be implicated. Conclusions: Large-scale and well-designed studies are needed to improve surveillance of the COVID-19 vaccine and better define possible adverse reactions involving the cochleo-vestibular system and/or immunisation anxiety-related reactions.

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One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms

Cited by 113 publications

References 92 publications

The Impact of COVID-19 and the Pandemic on Tinnitus: A Systematic Review

The Impact of COVID-19 and the Pandemic on Tinnitus: A Systematic Review

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Tinnitus following COVID-19 vaccination: report of three cases

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