2017
DOI: 10.1016/j.jped.2016.11.006
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One-year observational study of palivizumab prophylaxis on infants at risk for respiratory syncytial virus infection in Latin America

Abstract: The rate of RSV hospitalization in high-risk infants in Latin America was low and aligned with those observed in randomized control trials and observational studies. Palivizumab prophylaxis appeared effective and had a good safety profile in this population.

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Cited by 14 publications
(17 citation statements)
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“…The average number of doses of palivizumab injections during the study period was 3.5 doses/child, similar to that reported in Korea (3.7 doses) [18], Latin America (3.8 doses) [19] and in São Paulo (4 doses) [17]. Five doses of palivizumab were given to 34.6% of children, a percentage higher than reported in São Paulo (22.7%) [17] but lower than in Latin America (43.7%) [19]. Since palivizumab is only administered during the HRSV epidemic season (January to June in the North region of Brazil), the reduced number of doses could be a result of the difficulties of countryside children travelling to Belém in order to take their medication.…”
Section: Discussionsupporting
confidence: 83%
“…The average number of doses of palivizumab injections during the study period was 3.5 doses/child, similar to that reported in Korea (3.7 doses) [18], Latin America (3.8 doses) [19] and in São Paulo (4 doses) [17]. Five doses of palivizumab were given to 34.6% of children, a percentage higher than reported in São Paulo (22.7%) [17] but lower than in Latin America (43.7%) [19]. Since palivizumab is only administered during the HRSV epidemic season (January to June in the North region of Brazil), the reduced number of doses could be a result of the difficulties of countryside children travelling to Belém in order to take their medication.…”
Section: Discussionsupporting
confidence: 83%
“…The only study carried out previously in Mexican children that has been published was done as part of a multi‐national analysis of infants who received palivizumab . Because no separate data for participants from each country are provided, and because all children received palivizumab, it is difficult to compare our results with those reported in that study.…”
Section: Discussionmentioning
confidence: 96%
“…This work differs from earlier work by Wang et al 24,25 and Bentley et al 27 since the base case considers a lower number of doses of palivizumab (3.7 doses versus 5 doses). We believe that this is an appropriate approach for a number of reasons: it reflects real world evidence in the UK 33 and world-wide, [34][35][36][37] advice from UK clinicians supports this approach and the seasonality of the virus means that patients born in season and those in neonatal ICU in season will require fewer doses. 10…”
Section: Strengths and Limitationsmentioning
confidence: 90%
“…However, in this iteration of the model we chose to assume a dose of 3.7 reflecting the seasonality of infection and real-world evidence. 3,10,[33][34][35][36][37] The JCVI guidelines recommend that palivizumab is given from the beginning of the RSV season (October) and that infants in hospital should only receive palivizumab on discharge from the neonatal unit. 3 Recent consensus guidelines 10 state that children born during the RSV season will require fewer doses than those born before the season, which is confirmed by work we carried out around the seasonality of RSV for this publication.…”
Section: Number Of Dosesmentioning
confidence: 99%
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