One-year follow-up of optical coherence tomography angiography microvascular findings: macular telangiectasia type 2 versus tamoxifen retinopathy

Park, Yu Jeong; Lee, Suhwan; Yoon, Young Hee

doi:10.1007/s00417-022-05695-6

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Regarding pathogenesis, tamoxifen retinopathy shares common features with Macular Telangiectasia type 2 (MacTel) [9,10], including telangiectasia of macular blood vessels and crystalline deposits in the macula, as highlighted by various studies [11,12]. These similarities suggest potential overlapping mechanisms in the development of tamoxifen retinopathy and MacTel type 2, warranting further investigation into their shared pathophysiology.…”

Section: Discussionmentioning

confidence: 96%

“…These similarities suggest potential overlapping mechanisms in the development of tamoxifen retinopathy and MacTel type 2, warranting further investigation into their shared pathophysiology. For example, both conditions may involve vascular endothelial growth factor (VEGF) pathways and Muller cell defects in their pathogenesis, as suggested by recent research [9,10,13]. In addition, emerging evidence suggests a potential link between inflammation and tamoxifen-induced retinal changes [14], although further validation is needed to confirm this association.…”

Section: Discussionmentioning

confidence: 99%

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Nationwide Screening Practices for Tamoxifen Retinal Toxicity in South Korea: A Population-Based Cohort Study

Ahn,

Kim,

Kwon

2024

JCM

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(1) Background/Objectives: To investigate the nationwide screening practices and trends in tamoxifen retinal toxicity (tamoxifen retinopathy) in South Korea using national health insurance claims data. (2) Methods: A total of 43,848 patients who started tamoxifen therapy between 2015 and 2020 and had no prior ophthalmic diseases or other conditions requiring screening for retinopathy were included. The annual numbers of tamoxifen users and new initiators of tamoxifen therapy were assessed. The screening examinations were separated into baseline (first ophthalmic examination after tamoxifen administration) and subsequent monitoring examinations. The timing and modalities for the baseline and subsequent monitoring examinations performed between 2015 and 2021 were assessed in tamoxifen users. (3) Results: The annual number of tamoxifen users increased over the study period from 54,056 in 2015 to 81,720 in 2021. The number of patients who underwent ophthalmic examination after tamoxifen administration was 8961 (20.4%). Baseline screening was performed in 6.5% of patients within 1 year of use, and subsequent monitoring was performed in 27.8% of patients who underwent baseline screening. Funduscopy or fundus photography was performed most commonly for baseline screening and subsequent monitoring (99.0% and 98.6%, respectively), while optical coherence tomography was performed only in 21.9% and 29.6% of baseline and monitoring examinations, respectively. The average number of monitoring examinations per year was 0.68 ± 0.45. Although the annual percentage of patients receiving a baseline examination within 1 year gradually increased over time, the percentage of those with subsequent monitoring performed within 1 year was similar over the study period. (4) Conclusions: Our finding, appropriate screening in a small proportion of patients receiving tamoxifen, suggests the need to promote awareness among healthcare professionals and develop a standardized approach for screening for tamoxifen retinopathy.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Nationwide Screening Practices for Tamoxifen Retinal Toxicity in South Korea: A Population-Based Cohort Study

Ahn,

Kim,

Kwon

2024

JCM

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“…There is sufficient evidence in literature to demonstrate that discontinuation of tamoxifen therapy may cause reversal of ocular changes such as keratopathy and macular edema and may prevent progression to macular hole formation. 13,14 Hence, it is important to identify patients on tamoxifen therapy showing maculopathy changes at an early stage so as to allow the reversal of retinopathy changes following the discontinuation of the drug. Information regarding the diagnosis of tamoxifen maculopathy should be shared with the primary physician treating breast cancer so as to stop the drug and switch to alternative therapy if necessary.…”

Section: Discussionmentioning

confidence: 99%

Tamoxifen retinopathy and macular telangiectasia: A comparative case series

Venkatesh

Sharief

Jayadev

et al. 2022

European Journal of Ophthalmology

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Purpose To report a case series of tamoxifen retinopathy (TR) with and without type 2 macular telangiectasia (MacTel) and compare their clinical and imaging findings. Methods Retrospective comparative study. Female patients with tamoxifen use or with clinical diagnosis of type 2 MacTel were divided into 4 groups: Group A—tamoxifen use without retinopathy; Group B—tamoxifen use with retinopathy; Group C—type 2 MacTel with tamoxifen use and Group D—type 2 MacTel without tamoxifen use. Clinical and image analysis was conducted. Results There were 6 patients (11 eyes) in group A, 8 (13 eyes) patients in Group B, 2 patients (4 eyes) in Group C and 8 patients (14 eyes) in Group D respectively. TR patients were young, showed retinal crystals, perifoveal greying and no retinal pigment clumps (RPC) on examination. Foveal contour irregularity (n = 13, 100%) and outer retinal layer damage (n = 11, 85%) were common OCT findings seen in TR. In group C, all eyes showed 360° middle retinal layer (MRL) hyperreflectivity (100% vs 86%) and presence of outer retinal hyporeflective cavitation (100% vs 43%) on OCT compared to patients in group D. Abnormal autofluoroscence, detection and leakage from the telangiectatic vessels on fluorescein and OCT angiography was seen in type 2 MacTel disease. Conclusion Patients with TR showed retinal crystals and outer retinal hyporeflective foveal cavitation on OCT. Patients with type 2 MacTel having with tamoxifen intake showed hyporeflective outer retinal foveal cavitation and 360° perifoveal MRL hyperreflectivity on OCT. RPC was observed exclusively in the type 2 MacTel group.

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Tamoxifen

2023

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One-year follow-up of optical coherence tomography angiography microvascular findings: macular telangiectasia type 2 versus tamoxifen retinopathy

Cited by 4 publications

References 32 publications

Nationwide Screening Practices for Tamoxifen Retinal Toxicity in South Korea: A Population-Based Cohort Study

Nationwide Screening Practices for Tamoxifen Retinal Toxicity in South Korea: A Population-Based Cohort Study

Tamoxifen retinopathy and macular telangiectasia: A comparative case series

Tamoxifen

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