One-Year Follow-Up of a Randomized Controlled Trial Piloting a Mindfulness-Based Group Intervention for Adolescent Insulin Resistance

Abstract

Introduction To explore if a brief mindfulness-based intervention (MBI) leads to sustained, improved clinical outcomes in adolescents at-risk for type 2 diabetes (T2D). Methods Participants were 12–17y girls with overweight/obesity, elevated depression symptoms, and T2D family history participating in a randomized, controlled pilot trial of a six-session MBI vs. cognitive-behavioral therapy (CBT) group. At baseline and 1-year, mindfulness, depression, insulin resistance (IR), and body composition were assessed with validated instruments. Results One-year retention was 71% ( n = 12) in MBI; 81% ( n = 13) in CBT. At 1-year, depression decreased (Cohen’s d = 0.68) and IR decreased ( d = 0.73) in adolescents randomized to MBI compared to those in CBT. There were no significant between-condition differences in mindfulness, adiposity, or BMI. Discussion One-year outcomes from this randomized, controlled pilot trial suggest that brief MBI may reduce depression and IR in at-risk adolescents. Replication and exploration of mechanisms within the context of a larger clinical trial are necessary. Clinical Trial Registration www.ClinicalTrials.gov , identifier NCT02218138.

Synergistic effect of Vitamin D Supplement and mindfulness on insulin resistance and different aspects of cognitive function in Vitamin D Deficient Type 2 Diabetic mellitus (T2DM) women: A pilot randomized clinical trial with placebo-controlled

“…For example, in Shomaker (2019) research, mindfulness training reduced insulin resistance in diabetic adolescents with oneyear follow-up (8).Also various meta-analysis showed that vitamin D can reduce insulin resistance in different physical conditions (23,24 About e cacy of vitamin D and mindfulness on IR above researches showed similarity of our data with previous research literature. mindfulness with develops basic physiological and/or behavioral factors that in uence IR such as physical activity, eating habits, sleep behaviors, and stress arousal, reduce insulin resistance.…”

“…Another treatment that demonstrated promising results in T2DM is mindfulness. based on previous researches, mindfulness can improves underlying physiological and behavioral determinants that in uence insulin resistance such as stress arousal, physical activity, sleep quality, and eating unhealthy habits (8). Also This treatment with improvement in immediate memory, thinking, and attention, can enhance cognitive function.…”

“…moreover, when vitamin D and mindfulness used as monotherapy, although they are effective, but they have on average, a small effect size. There has accordingly been interesting in consolidating pharmacological and psychotherapeutic treatments in a trial to improve effectiveness (7)(8)(9)(10).Also, behavioral intervention with improve empathy and therapeutic alliance, so enhance drug compliance. Therefore, Regarding with this combination, we can directly and indirectly modify problems (11,12).…”

Update: Pediatric Diabetes

“…A recent randomized controlled trial by Shomaker et al explored the effect of brief MBIs and their relationship to sustained improved clinical outcomes in adolescents at risk for T2D …”

“…A recent randomized controlled trial by Shomaker et al explored the effect of brief MBIs and their relationship to sustained improved clinical outcomes in adolescents at risk for T2D. 7 This study is a single-center study that was conducted in adolescent girls between 12 and 17 years of age who were overweight or obese (BMI > 85%) with family history of T2D and depressive symptoms (total score ≥ 16 on the Center for Epidemiologic Studies Depression Scale).…”