One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats

Nakayama, Shouta M.M.; Nakata, Hokuto; Ikenaka, Yoshinori; Yabe, John; Oroszlany, Balazs; Yohannes, Yared Beyene; Bortey-Sam, Nesta; Muzandu, Kaampwe; Choongo, Kennedy; Kuritani, Takeshi; Nakagawa, Mitsuhiro; Ishizuka, Mayumi

doi:10.1016/j.envpol.2019.05.038

Cited by 43 publications

(13 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rats exposed to Cd (1, 2, or 4 mg/kg/day) on days 3-7 after birth causes abnormal DNA methylation on day 70 after birth and increases sperm apoptosis, and exhibits a degradation of seminiferous tubules (Zhu et al, 2011). Exposure of rats to Cd-contaminated soil for 1 year leads to Cd accumulation and increases the genome-wide methylation status and the expression of DNA methyltransferase (Dnmt 3a/3b) in the testis, suggesting epigenetic changes (Nakayama et al, 2019). Treatment of mouse TM3 LC cell line with Cd can downregulate the expression of DNA methyltransferase (Singh et al, 2009), also indicating an epigenetic regulation and a possible cancer formation.…”

Section: Epigenetic Regulation Of CDmentioning

confidence: 99%

Toxicological Effects of Cadmium on Mammalian Testis

Zhu

2020

Front. Genet.

View full text Add to dashboard Cite

Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis. In this review, we summarize the effects of cadmium on the development and function of the testis. Cadmium causes severe structural damage to the seminiferous tubules, Sertoli cells, and blood-testis barrier, thus leading to the loss of sperm. Cadmium hinders Leydig cell development, inhibits Leydig cell function, and induces Leydig cell tumors. Cadmium also disrupts the vascular system of the testis. Cadmium is a reactive oxygen species inducer and possibly induces DNA damage, thus epigenetically regulating somatic cell and germ cell function, leading to male subfertility/infertility.

show abstract

Section: Epigenetic Regulation Of CDmentioning

confidence: 99%

Toxicological Effects of Cadmium on Mammalian Testis

Zhu

2020

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…In fact, a prolonged (1 year) study on the exposure of rats to Pbcontaminated soil has shown that Pb can accumulate in tissues without exposure via food sources. 50 In that study, the Pb accumulation ratio of lungs to livers was also found to be high (0.432). Studies in the field of occupational exposure show that the absorption rate of Pb from the lungs is 40−50% after the Pb reaches the alveolar region, 51 while that from the digestive tract is only 10%.…”

Section: Metal and As Concentrations In Lizardsmentioning

confidence: 71%

Land Use in Habitats Affects Metal Concentrations in Wild Lizards Around a Former Lead Mining Site

Doya

Nakayama

Nakata

et al. 2020

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

We investigated the potential effects of different land use and other environmental factors on animals living in a contaminated environment. The study site in Kabwe, Zambia, is currently undergoing urban expansion, while lead contamination from former mining activities is still prevalent. We focused on a habitat generalist lizards (Trachylepis wahlbergii). The livers, lungs, blood, and stomach contents of 224 lizards were analyzed for their lead, zinc, cadmium, copper, nickel, and arsenic concentrations. Habitat types were categorized based on vegetation data obtained from satellite images. Multiple regression analysis revealed that land use categories of habitats and three other factors significantly affected lead concentrations in the lizards. Further investigation suggested that the lead concentrations in lizards living in bare fields were higher than expected based on the distance from the contaminant source, while those in lizards living in green fields were lower than expected. In addition, the lead concentration of lungs was higher than that of the liver in 19% of the lizards, implying direct exposure to lead via dust inhalation besides digestive exposure. Since vegetation reduces the production of dust from surface soil, it is plausible that dust from the mine is one of the contamination sources and that vegetation can reduce exposure to this.

show abstract

“…Such exposure to heavy metals involves alterations in gene expression. 67,68 Other studies in the Zambian city of Kabwe showed heavy metal contamination in the muscular system of fish belonging to the Serranochromis genus 69 , and in liver, lung, stomach, and blood samples obtained from local lizards (Trachylepis wahlbergii) 70 .…”

Section: Southeast African Countriesmentioning

confidence: 99%

Chemical pollution as a driver of biodiversity loss and potential deterioration of ecosystem services in Eastern Africa: A critical review

Cristiano

Giacoma

Carere³

et al. 2021

S. Afr. J. Sci.

View full text Add to dashboard Cite

Chemical pollution, i.e. the release of anthropogenic chemical substances into the environment, is a driver of biodiversity loss. Although this issue has been widely investigated in high-income countries of temperate regions, there is a lack of data for tropical areas of middle- or low-income countries, such as those in Eastern Africa. Some of the world’s richest biomes that are affected by multiple pressures, including chemical pollution, are hosted in this macro-region. However, few studies have addressed the impact of the release of anthropogenic chemical pollutants on the biodiversity, and the related potential implications for the deterioration of ecosystem goods and services in this area. A contribution in systemising the scientific literature related to this topic is, therefore, urgently needed. We reviewed studies published from 2001 to 2021, focusing on the chemical pollution impact on Eastern African wildlife. Despite an extensive literature search, we found only 43 papers according to our survey methods. We focused on wildlife inhabiting terrestrial ecosystems and inland waters. According to our search, Kenya and Uganda are the most represented countries accounting for about half of the total number of reviewed articles. Moreover, 67.4% of the studies focus on inland waters. The spread of anthropogenic chemicals into tropical areas, e.g. Eastern Africa, and their effects on living organisms deserve greater attention in research and politics. We report a weak increasing trend in publishing studies addressing this topic that might bode well. The combined effort of science and governments is crucial in improving the management of chemical pollutants in the environment for achieving the goals of biodiversity conservation.

show abstract

One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats

Cited by 43 publications

References 56 publications

Toxicological Effects of Cadmium on Mammalian Testis

Toxicological Effects of Cadmium on Mammalian Testis

Land Use in Habitats Affects Metal Concentrations in Wild Lizards Around a Former Lead Mining Site

Chemical pollution as a driver of biodiversity loss and potential deterioration of ecosystem services in Eastern Africa: A critical review

Contact Info

Product

Resources

About