One-year experience with 68Ga-PSMA PET/CT: applications and results in biochemical recurrence of prostate cancer

Abstract

ObjectiveTo show the initial (first-year) experience with 68Ga-PSMA PET/CT at a clinic in Brazil.Materials and MethodsOver a one-year period, 96 examinations with 68Ga-PSMA PET/CT (85 related to prostate cancer and 11 related to kidney cancer) were performed in 90 patients.ResultsIn the prostate and kidney cancer patients alike, the main clinical indication for 68Ga-PSMA PET/CT was suspicion of recurrence during follow-up (in 65.8% and 63.0% of the cases, respectively). Among the prostate cancer patients, 38.5% of those with a prostate specific antigen (PSA) < 0.5 ng/mL tested positive for recurrence on 68Ga-PSMA PET/CT, compared with 71.0% of those with a PSA of 0.5-0.99, 85.7% of those with a PSA of 1.0-1.99, and 92.6% of those with a PSA > 1.99.ConclusionAlthough 68Ga-PSMA PET/CT is a technique that has only recently been applied in clinical settings, despite its high cost, 68Ga-PSMA PET/CT shows great promise as a tool in the clinical management of patients with kidney and prostate cancer, especially in those with prostate cancer whose PSA levels are elevated even after treatment.

Performance and Impact of Prostate Specific Membrane Antigen-Based Diagnostics in the Management of Men with Biochemical Recurrence of Prostate Cancer and its Role in Salvage Lymph Node Dissection

“…74% for very low and low PSA values, respectively. These important findings were in line with other retrospective evaluations making the clinician understand that diagnostic PSMA PET/CT scans may be of use if imaging will have an impact in treatment strategy at PSA-levels below 0.5 ng/mL [1213].…”