One year after Vanda, are diagnostics patents transforming into methods of treatment to overcome Mayo-based rejections?

Abstract

On the first anniversary of Vanda, 1) to what extent have legal arguments and claim amendments based on Vanda been effective in overcoming 35 USC 101 Mayo-based rejections?; and 2) How are applicants transforming diagnostic patent claims into method of treatment claims to overcome Mayo-based subject matter eligibility rejections?