One week eradication regimen for Helicobacter pylori

Logan, R. P. H.; Gummett, P. A.; Misiewicz, J. J.; Karim, Q. N.; Walker, M M; Baron, J. H.

doi:10.1016/0140-6736(91)92111-e

Cited by 139 publications

(40 citation statements)

References 10 publications

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“…2±4 The ®rst consistently successful therapy was triple therapy consisting of metronidazole (MNZ) plus bismuth and either tetracycline or amoxycillin (AMOX), which can cure H. pylori infection in over 80% of patients. 5,6 Unfortunately, this therapy requires that a large number of pills be taken daily at an inconvenient four times daily dosing schedule, and troublesome sideeffects occur frequently. 7 Concomitant therapies consisting of a proton pump inhibitor and one or two antibiotics have been developed to reduce the sideeffects and to improve patient tolerance and compliance.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan

Miyaji

Azuma

Ito

et al. 1997

Aliment Pharmacol Ther

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Background:Primary and acquired resistance to antibiotics is an important factor in determining the reason for treatment failure in Helicobacter pylori infection. We examined the relationship between the susceptibility of H. pylori isolates and the efficacy of chemotherapy.Methods:The minimal inhibitory concentrations (MICs) of metronidazole (MNZ), clarithromycin (CLAR) and amoxycillin (AMOX) of 320 H. pylori pre‐treatment isolates were determined by the agar dilution method. In 290 patients with peptic ulcers, H. pylori infection was treated by dual or triple combination therapies for 2 weeks: one proton pump inhibitor (30 mg/day lansoprazole or 20 mg/day omeprazole) and one or two antibiotics (500 mg AMOX, 200 mg CLAR or 250 mg MNZ twice a day). MICs were also determined after the treatment failure.Results:Among the drugs tested, for MNZ and CLAR, 8.1% and 9.1% of the isolates, respectively, were resistant, while no isolate was resistant to AMOX. After unsuccessful treatment using MNZ and CLAR, 66.7% and 70.6% of the isolates changed from sensitive to resistant, respectively. All isolates were sensitive to AMOX after treatment failure.Conclusions:The failure of the H. pylori treatment results in the induction of resistance to CLAR and/or MNZ. Regimens with a high cure rate should be used in order to prevent the generation of acquired resistance to antibiotics.

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Section: Introductionmentioning

confidence: 99%

Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan

Miyaji

Azuma

Ito

et al. 1997

Aliment Pharmacol Ther

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“…Several therapeutic regimens have been proposed to clear H. pylori infections and to obtain a long-term eradication of the microorganism (6,9,15,17).…”

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Helicobacter pylori: A Fickle Germ

Cellini

Allocati

Campli

et al. 1994

Microbiology and Immunology

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The morphologic changes from bacillary to coccoid forms of Helicobacter pylori were studied. These form changes were analyzed by bacterial growth in Brucella broth plus 2% fetal calf serum. The coccoid forms were observed at five days of incubation and a rapid decrease of CFU/ml was recorded. At two weeks of microaerophilic incubation, all coccoid forms observed were not culturable in vitro. The coccoid morphology was observed earlier when the culture of H. pylori was incubated in aerobic conditions and with subinhibitory concentrations of omeprazole and roxithromycin. To evaluate the possibility of resistance of coccal forms, before plating, the cultures were heated to 80 C for 10 min and sonicated. In the absence of these treatments the cultures did not show growth in vitro. The proteic patterns of the same strains of two different morphologies were studied revealing significant differences.

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“…AIDS 1988;2:369-7 1. 4 Robertson P, Burns SM, Yap P1L, Mok JYQ, Parrn'IJ. ''he use of saliva and urine in the detection of HIV infection in children: preliminary report.…”

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confidence: 99%