One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation

Brännström, Mats; Bokström, Hans; Dahm‐Kähler, Pernilla; Díaz-García, César; Ekberg, Jana; Enskog, Anders; Hagberg, Henrik; Johannesson, Liza; Kvarnström, Niclas; Mölne, Johan; Olausson, Michael; Olofsson, Jan I.; Rodriguez‐Wallberg, Kenny A.

doi:10.1016/j.fertnstert.2016.04.001

Cited by 138 publications

(79 citation statements)

References 19 publications

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“…In that study, the uterus was preserved post-partum, and immunosuppressive therapy was continued to attempt a second gestation in certain patients. Furthermore, the birth of healthy babies from organ-transplanted women has confirmed the efficacy and safety of certain immunosuppressive therapy during gestation following uterus transplantation 13,18,23,24.…”

Section: Discussionmentioning

confidence: 90%

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Uterine transplantation: a systematic review

Ejzenberg¹,

Mendes²,

Haddad³

et al. 2016

Clinics

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Up to 15% of the reproductive population is infertile, and 3 to 5% of these cases are caused by uterine dysfunction. This abnormality generally leads women to consider surrogacy or adoption. Uterine transplantation, although still experimental, may be an option in these cases. This systematic review will outline the recommendations, surgical aspects, immunosuppressive drugs and reproductive aspects related to experimental uterine transplantation in women.

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Section: Discussionmentioning

confidence: 90%

“…At discharge from the hospital, the baby weighed 2040 g 13. The two subsequent births reported occurred without complications 18.…”

Section: Methodsmentioning

confidence: 98%

Uterine transplantation: a systematic review

Ejzenberg¹,

Mendes²,

Haddad³

et al. 2016

Clinics

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show abstract

“…The donor uterus can be harvested from a deceased or live donor and multiparous women with a live birth to miscarriage ration of [1 should be preferred [103]. Nine uterine transplant cases have been performed by Dr. Brännström and colleagues to date and 7 of the 9 women have become pregnant, resulting in 5 successful deliveries [105,106]. In the United States, two uterus transplant trials are currently under way, one at the Cleveland Clinic and one at the Baylor University Medical Center [106].…”

Section: Uterus Transplantationmentioning

confidence: 99%

Mullerian dysgenesis: a critical review of the literature

Choussein

Nasioudis

Schizas

et al. 2017

Arch Gynecol Obstet

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“…Two women became pregnant at their first embryo transfer [6, 47] attempts and the first live birth after UTx took place in September 4, 2014 [6]. In that pregnancy, in a patient with uterine and unilateral renal agenesis, preeclampsia developed at gestational week 31 + 5.…”

Section: Introductionmentioning

confidence: 99%

Uterus transplantation and beyond

Brännström

2017

J Mater Sci: Mater Med

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Uterus transplantation is today the only available treatment for absolute uterine factor infertility which is caused by either congenital/surgical uterine absence or that a present uterus is non-functioning. Structured animal-based research, from rodents to nonhuman primates, was the scientific basis for a successful introduction of uterus transplantation as a clinical procedure. The patient groups for uterus transplantation, the preclinical research and data from the published human cases will be covered herein. During recent years the concept of bioengineering of organs and tissues has emerged. Creation of a bioengineered uterus is in the initial research state, with experiments performed in rodents. The research that has been performed to create a bioengineered uterus will be summarized. In conclusion, uterus transplantation is now a clinical experimental procedure for treatment of uterine factor infertility. In parallel to the establishment of this combined assisted reproduction technique and transplantation procedure as a routine clinical procedure, we predict that uterus bioengineering will develop further towards introduction within the human setting, but that this process will take several years.

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One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation

Abstract: NCT01844362.

Cited by 138 publications

References 19 publications

Uterine transplantation: a systematic review

Uterine transplantation: a systematic review

Mullerian dysgenesis: a critical review of the literature

Uterus transplantation and beyond

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