One Thousand Consecutive Midtrimester Amniocenteses

Fk, Bartsch; Lundberg, J; Wahlström, Jan

doi:10.1097/00006250-198003000-00007

Cited by 19 publications

(11 citation statements)

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“…The rate of foetal death after genetic amniocentesis is generally thought to be very low. In the past three decades, many studies and collaborative trials have reported that the rate of foetal deaths ranges from 0.06% to 2.9% (Table 1) (JAMA, 1976;Simpson et al, 1976; MRC Working Party on Amniocentesis, 1978; Bartsch et al, 1980;Crandall et al, 1980;Tabor et al, 1986; The Canadian Early and Mid-trimester Amniocentesis Trial (CEMAT) Group, 1998;Caughey et al, 2006;Eddleman et al, 2006). The rate established by the Centre for Disease Control and Prevention-0.5% lost pregnancies after amniocentesis (JAMA, 1976;Simpson et al, 1976)-is often cited; however, the source of this data has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Prophylaxis before second‐trimester Genetic Amniocentesis (APGA): a single‐centre open randomised controlled trial

Giorlandino¹,

Cignini²,

Cini

et al. 2009

Prenatal Diagnosis

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Objective To compare procedure-related pregnancy loss after second-trimester genetic amniocentesis in women given an antibiotic prophylaxis and controls.Methods Prospective, open randomised controlled single-centre study between January 1999 and December 2005 at Artemisia Fetal Maternal Medical Centre. A follow-up within 4 weeks after the procedure was done.Of 36 347 eligible women, 1424 refused to participate and 34 923 were enrolled and randomised with unequal chance of selection, 21 991 were assigned to treatment group and 12 932 were assigned to the control group, and did not receive any placebo. Oral azithromycin, 500 mg per day, was administered 3 days before amniocentesis. The primary endpoint was the procedure-related pregnancy loss. The secondary endpoint was the rate of preterm premature rupture of membranes. ResultsThe rate of abortion related to the amniocentesis was 7/21 219 women (0.03%, 95% CI 0.009-0.057) in the intervention group, and 36/12 529 (0.28%, 0.28-0.30) in controls (p = 0.0019). The rate of preterm premature rupture of membranes was 14/21 219 (0.06%, 0.031-0.101) in the intervention group, and 140/12 529 (1.12%, 0.94-1.30) in the control group (p = 0.001).Conclusions Antibiotic prophylaxis before second-trimester amniocentesis reduced the risk of abortion and of rupture of the membranes.

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Section: Introductionmentioning

confidence: 99%

Antibiotic Prophylaxis before second‐trimester Genetic Amniocentesis (APGA): a single‐centre open randomised controlled trial

Giorlandino¹,

Cignini²,

Cini

et al. 2009

Prenatal Diagnosis

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“…En effet, dans les 14 études qui ont été utilisées pour fin de comparaison des motifs d'amniocentèse, 6 seulement présentaient des résultats globaux (Simpsons et al 1976;Henry et al 1978;Hsu et al 1978;Golbus et al 1979;Daniel et al 1982;Schmid 1990). Les autres auteurs s'attardaient plus spécifiquement aux anomalies chromosomiques trouvées dans les cellules amniotiques de patientes ayant consulté pour âge maternel avancé (Crandall et al 1980;Bartsch et al 1976;Dacus et al 1985).…”

Section: Résultatsunclassified

“…Malheureusement, les découvertes fortuites ne font pas l'objet d'une discussion dans les autres études publiées (Young et al 1975;Crandall et al 1980;Stene et al 1984;Henry et ai 1978;Hsu et al 1978;Hanson et al 1985;Dacus et al 1985;Leshot et al 1985;Bartsch et al 1976;Tabor et al 1986;Tabor et Philip 1987;Davidson et al 1987;Eydoux et al 1989;Wolstenholme et al 1988).…”

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“…Les multiples avantages de l'échographie lors de la procédure font l'objet de plusieurs articles (Hsu et al 1978;Tabor et al 1976;Bartsch et al 1976;Hanson et al 1985;Dacus et al 1985). L'échographie ne se limite pas à déterminer l'âge de la grossesse, elle est un outil précieux au niveau du diagnostic prénatal car elle permet de diagnostiquer plusieurs anomalies.…”

Section: Solutionsunclassified

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Amniocenteses et anomalies genetiques a l hopital de Chicoutimi

Hamel¹

1991

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“…The safety of the procedure has been assessed by several large collaborative trials [2][3][4][5][6][7][8][9] which documented a procedure related risk of 0.5% to 1.3%, beyond an independent (background) risk of approximately 3% 8 . Most of these studies were performed almost 20 years ago when amniocentesis was a new procedure, ultrasound machines were inferior to current models, and the operators' experience was limited.…”

Section: Introductionmentioning

confidence: 99%

Risk factors predisposing to fetal loss following a second trimester amniocentesis

Papantoniou

Tziotis

Kitmirides

et al. 2001

BJOG

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Objective To examine the influence of possible risk factors on fetal loss rate following amniocentesis.Design Retrospective analysis of case records between 1993 and 1998. Setting Fetal medicine unit of a large teaching hospital.Population One thousand and six women with singleton pregnancies formed the study group. Seven hundred and eight of them had bleeding during the current pregnancy before the procedure, while 298 had a history of three or more first trimester abortions and/or a second trimester miscarriage or termination of pregnancy. Four thousand and twenty-four women who had amniocentesis and had no risk factors served as controls. Both groups were also classified according to maternal age. Group 1: 1610 women aged 20-34 years; Group 2: 2850 women aged 35-39 years; Group 3; 570 women . 40 years. Methods Women of both groups underwent a second trimester amniocentesis between 16 and 21 weeks of gestation. Fetal losses following amniocentesis were examined in three time intervals: 1. in the first two weeks after the procedure; 2. up to the 28 th week; 3. from the 28 th week to term.Results There was a statistically significant difference in the fetal loss rate between women aged 20-34 years (2.54%) and those . 40 years (5.1%). Women with a history of vaginal bleeding during the current pregnancy had a higher fetal loss rate compared with controls (6.5% vs 2.8%), which corresponds to an odds ratio of 2.4 (95% CI 1.69-3.42). A similar difference was found between the group of women with a history of previous abortions/terminations and the controls (8% vs 2.8%): OR 3.03 (95% CI 1.92-4.79). Conclusions There is a higher risk of fetal loss following amniocentesis in women . 40 years of age compared with those aged 20-34 years. Bleeding in the current pregnancy, a history of three or more first trimester abortions, a second trimester miscarriage or termination of pregnancy seem to be significant predisposing factors for fetal loss after an amniocentesis.

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One Thousand Consecutive Midtrimester Amniocenteses

Cited by 19 publications

References 0 publications

Antibiotic Prophylaxis before second‐trimester Genetic Amniocentesis (APGA): a single‐centre open randomised controlled trial

Antibiotic Prophylaxis before second‐trimester Genetic Amniocentesis (APGA): a single‐centre open randomised controlled trial

Amniocenteses et anomalies genetiques a l hopital de Chicoutimi

Risk factors predisposing to fetal loss following a second trimester amniocentesis

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