One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation

Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review

“…Majority of the compounds were found to be active against the employed strains [65]. Garudachari et al carried out synthesis of quinoline incorporated benzimidazole derivatives and screened them for in-vitro antimicrobial and antifungal activities by well plate method.…”

Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: assessment of their antimicrobial, antituberculosis and antioxidant activity

“…Thus, in view of the biological significance of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione, a modification on the 1-position of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione by 3-methyl-5-phenoxy-1-phenyl-1H-pyrazole was undertaken to check whether it brings significant changes in the bioactivities of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives. As a part of our current study in developing new antimicrobial agents via combination of two therapeutically active moieties [22][23][24][25], we report herein the C. B. Sangani et al preparation 1H-pyrazolo[1,2-b]phthalazine-5,10-dione 4a-p derivatives by an MCR approach.…”

“…In continuation of our interest on synthesizing biologically potent antimicrobials [22][23][24][25], we report herein a new series of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives (4a-p) via one-pot, three-component base-catalyzed cyclo condensation reaction of 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde (1a-d), malononitrile or ethyl cyanoacetate (2a-b) and 2,3-dihydro-1,4-phthalazinedione (3a-b) in ethanol containing eco friendly base NaOH in good to excellent yields (Scheme 1). The required starting material, 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde was prepared by using the procedure in the literature [26].…”

“…The required starting material, 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde was prepared by using the procedure in the literature [26]. 1-Aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde undergoes a nucleophilic substitution reaction with respective phenol at refluxing temperature for 4 h in the presence of a basic catalyst (K2CO3) in DMF which resulted in the required 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde [22,23]. A possible mechanism for the reaction is outlined in Scheme 2.…”

Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents

“…These compounds have many activities, such as anti-histamine [1], anti-microbial [2], and anti-tumor [3] properties.…”