One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections

Zhu, Yingnan; Zhang, Jiamin; Song, Jiayin; Yang, Jing; Xu, Tong; Pan, Chao; Zhang, Lei

doi:10.1039/c7tb02477k

Cited by 82 publications

(47 citation statements)

References 42 publications

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“…The biggest obstacle to wound healing is infections that can lead to systemic complications [25,26]. Sustained delivery of bioactive agents was reported as highly beneficial for wounds.…”

Section: Introductionmentioning

confidence: 99%

Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

et al. 2020

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We developed the interpenetrating double network composite hydrogel based on poly (vinyl alcohol) (PVA) and fish gelatin (FG) via thermal treatment and repeated freeze-thawing. A function of salicylic acid was incorporated into the hydrogel to improve its antibacterial properties. The color values, water contents, water evaporation rate, and swelling behavior were investigated. The drug-loading performance of the composite hydrogel was demonstrated by loading salicylic acid in various hydrogel systems. Moreover, the cumulative dissolution percentage of salicylic acid and the antibacterial activity of composite hydrogel were carried out. The results revealed that as FG concentration increased from 0% to 3.75% (w/v), gels changed from white to slight yellow and the swelling ratio increased from 54% to 83% (within 8 h). The presence of FG decreased the water content of gels which ranged from 86% to 89% and also decreased water evaporation rate. All gels presented the swelling index within 0.5–1.0, indicating a non-Fickian diffusion mechanism. The drug sustained dissolution behavior of pure PVA and composite hydrogel showed the same trend. Besides, the presence of the obvious bacteriostatic zones means that drug-loaded composite hydrogels have an effective antibacterial property. These results demonstrated that PVA/FG-based interpenetrating hydrogel is an appropriate biomaterial for drug-carrying wound dressing application.

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“…The biggest obstacle to wound healing is infections that can lead to systemic complications [25,26]. Sustained delivery of bioactive agents was reported as highly beneficial for wounds.…”

Section: Introductionmentioning

confidence: 99%

Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

et al. 2020

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“…A large number of silver formulations have been employed to elucidate the antibacterial activity of AgNPs [14–17], for example, a wound dressing through a zwitterionic polycarboxybetaine hydrogel along with antibacterial AgNPs as core component proposed by Zhang et al . [18], the multifunctional surfaces obtained via multicomponent coating for co-immobilizing AgNPs proposed by Moreno-Couranjou et al, etc. [19] .…”

Section: Introductionmentioning

confidence: 99%

Facile In Situ Preparation and In Vitro Antibacterial Activity of PDMAEMA-Based Silver-Bearing Copolymer Micelles

Lin

Huang

et al. 2019

Nanoscale Res Lett

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Well-defined polymer micelles with core-shell structure are good delivery platform for stabilizing silver nanoparticles (AgNPs) in the field of antimicrobials targeting diseases. The rational construction of the polymer structure, an efficient, facile, and green preparation approach, and comprehensive exploration of the derived AgNPs are necessary, such as size, particle stability, antibacterial activity, and other properties. Herein, we designed and assessed the in vitro antimicrobial activity of AgNPs-decorated copolymer micelles with different copolymer topologies. First, linear or four-arm star triblock copolymers with the similar molecular weight and degree of polymerization were obtained, which consisted of DMAEMA for in situ reduction of silver ions to form AgNPs without external reducing agent. HEMA and PEGMA in micellar shell gave an enhanced stability of AgNPs during blood circulation. The combination of computational modeling and experimental results indicated that both types of micelles could fabricate AgNPs with monodisperse and spherical morphology. Star copolymer micelles stabilized AgNPs had smaller average size, better stability, and higher antibacterial activity than those with linear structure, which may due to higher stability of micelles from star copolymers. Furthermore, the cytotoxicity evaluation test showed that the achieved linear or star copolymers micelles stabilized AgNPs had good biocompatibility. This work provides a facile and universal approach in the rational design of micelles stabilized AgNPs with suitable topology for fighting against a wide range of bacterial infections. Electronic supplementary material The online version of this article (10.1186/s11671-019-3074-z) contains supplementary material, which is available to authorized users.

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“…Metal Ion Inorganic Antibacterial Agents: Metal ions (e.g., Ag + , Cu 2+ , Zn 2+ , Co 2+ ) are widely used in a variety of metal ion-based antibacterial materials because of their broad-spectrum antibacterial properties and nonresistance to antibiotics such as antibacterial implants, [23,24] wound dressings, [25] water disinfection, [26] and a range of other antibacterial products. [27] At present, the use of silver ions for antibacterial applications is still a hot spot for researchers.…”

Section: 1 Inorganic Antibacterial Agentsmentioning

confidence: 99%

Antibacterial Hybrid Hydrogels

Cao

Luo

et al. 2020

Macromolecular Bioscience

123

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Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over the world. In view of the increased bacteria resistance caused by overuse or improper use of antibiotics, antibacterial biomaterials are developed as the substitutes for antibiotics in some cases. Among them, antibacterial hydrogels are attracting more and more attention due to easy preparation process and diversity of structures by changing their chemical cross‐linkers via covalent bonds or noncovalent physical interactions, which can endow them with various specific functions such as high toughness and stretchability, injectability, self‐healing, tissue adhesiveness and rapid hemostasis, easy loading and controlled drug release, superior biocompatibility and antioxidation as well as good conductivity. In this review, the recent progress of antibacterial hydrogel including the fabrication methodologies, interior structures, performances, antibacterial mechanisms, and applications of various antibacterial hydrogels is summarized. According to the bacteria‐killing modes of hydrogels, several representative hydrogels such as silver nanoparticles‐based hydrogel, photoresponsive hydrogel including photothermal and photocatalytic, self‐bacteria‐killing hydrogel such as inherent antibacterial peptides and cationic polymers, and antibiotics‐loading hydrogel are focused on. Furthermore, current challenges of antibacterial hydrogels are discussed and future perspectives in this field are also proposed.

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One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections

Abstract: A PCB–AgNP hydrogel was fabricated using a one-step method and demonstrated to efficiently treat wound infections.

Cited by 82 publications

References 42 publications

Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

Facile In Situ Preparation and In Vitro Antibacterial Activity of PDMAEMA-Based Silver-Bearing Copolymer Micelles

Antibacterial Hybrid Hydrogels

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