One-step synthesis of 2,3-difluoronaphthalene by the gas-phase co-pyrolysis of styrene with chlorodifluoromethane

Volchkov, N. V.; Lipkind, M. B.; Нефедов, О. М.

doi:10.1007/s11172-019-2546-8

Cited by 7 publications

(2 citation statements)

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“…Amii and co-workers compared the efficiency of the two reagents, ClCF 2 COONa (12) and BrCF 2 COONa (17), in the difluorocyclopropanation of 1,1-diphenylethene ( 18) [29] and the results are summarized in Table 1. They showed that it was easier and more efficient to work with sodium bromodifluoroacetate (17). The application of the same conditions resulted in almost 100% yield, when using 17.…”

Section: Chloro-and Bromodifluoroacetate Salts As Difluorocarbene Sourcesmentioning

confidence: 99%

“…The yields were best in the reactions with electron-rich alkenes and when a low concentration of the base was used to minimize the destruction of difluorocarbene. The use of oxirane or epichlorohydrin as hydrogen halide scavengers avoided the need for a stoichiometric amount of the strong base [ 16 – 17 ]. The opening of the oxirane ring by bromide ions under homogeneous conditions generated a bromoalkoxide ion which then acted as the base, leading to cyclopropanes 4 and 6 ( Scheme 2 ).…”

Section: Reviewmentioning

confidence: 99%

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The preparation and properties of 1,1-difluorocyclopropane derivatives

Adekenova¹,

Wyatt²,

Адекенов³

2021

Beilstein J. Org. Chem.

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Recently, the functionalization of organic molecules with fluorine substituents has grown rapidly due to its applications in such fields as medicine, agriculture or materials sciences. The aim of this article is to review the importance of 1,1-difluorocyclopropane derivatives in synthesis. It will examine the role of the fluorine substituents in both ring-forming and ring-opening reactions, as well as methods for obtaining difluorocyclopropanes as single enantiomers. Several examples are provided to highlight the biological importance of this class of compounds.

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Section: Chloro-and Bromodifluoroacetate Salts As Difluorocarbene Sourcesmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%