Indium oxide (In 2 O 3) tower-shaped nanostructure gas sensors have been fabricated on Cr comb-shaped interdigitating electrodes with relatively narrower interspace of 1.5 μm using thermal evaporation of the mixed powders of In 2 O 3 and active carbon. The Schottky contact between the In 2 O 3 nanotower and the Cr comb-shaped interdigitating electrode forms the Cr/In 2 O 3 nanotower Schottky diode, and the corresponding temperature-dependent I-V characteristics have been measured. The diode exhibits a low Schottky barrier height of 0.45 eV and ideality factor of 2.93 at room temperature. The In 2 O 3 nanotower gas sensors have excellent gas-sensing characteristics to hydrogen concentration ranging from 2 to 1000 ppm at operating temperature of 120-275°C, such as high response (83 % at 240°C to 1000 ppm H 2), good selectivity (response to H 2 , CH 4 , C 2 H 2 , and C 3 H 8), and small deviation from the ideal value of power exponent β (0.48578 at 240°C). The sensors show fine long-term stability during exposure to 1000 ppm H 2 under operating temperature of 240°C in 30 days. Lots of oxygen vacancies and chemisorbed oxygen ions existing in the In 2 O 3 nanotowers according to the x-ray photoelectron spectroscopy (XPS) results, the change of Schottky barrier height in the Cr/In 2 O 3 Schottky junction, and the thermoelectronic emission due to the contact between two In 2 O 3 nanotowers mainly contribute for the H 2 sensing mechanism. The growth mechanism of the In 2 O 3 nanotowers can be described to be the Vapor-Solid (VS) process.