One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery

Chen, Jingqin; Liu, Hongyu; Zhao, Chubiao; Qin, Guiqi; Xi, Gaina; Li, Tan; Wang, Xiaoping; Chen, Tongsheng

doi:10.1016/j.biomaterials.2014.02.032

Cited by 173 publications

(133 citation statements)

References 41 publications

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“…In addition to all these studies, several other graphene-based nanotherapeutic platforms such as CuS nanoparticle decorated GO, PEGylated graphene nanoribbons, Fe 3 O 4 nanoparticle loaded GO nanocomposites have been developed for combined chemo-photothermal therapy of cancer. [103][104][105][106][107][108] …”

Section: Combined Chemo-pttmentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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Graphene and graphene-based nanomaterials such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene quantum dots (GQDs) have gained a lot of attention from diverse scienti¯c¯elds for applications in sensing, catalysis, nanoelectronics, material engineering, energy storage and biomedicine due to its unique structural, optical, electrical and mechanical properties. Graphene-based nanomaterials emerge as a novel class of nanomedicine for cancer therapy for several reasons. Firstly, its structural properties like high surface area and aromaticity enables easy loading of hydrophobic drugs. Secondly, presence of oxygen containing functional groups improve its physiological stability and also act as site for biofunctionalization. Thirdly, its optical absorption in the NIR region enable them to act as photoagents for photothermal and photodynamic therapies of cancer, both in vitro and in vivo. Finally, its intrinsic°u orescence property helps in bioimaging of cancer cells. Overall, graphene-based nanomaterials can act as agents for developing multifunctional theranostic platforms for carrying out more e±cient detection and treatment of cancers. This review provides a detailed summary of the di®erent applications of graphene-based nanomaterials in drug delivery, nucleic acid delivery, phototherapy, bioimaging and theranostics.

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Section: Combined Chemo-pttmentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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“…[27][28][29] Therefore, various new strategies, including encapsulation of RSV into lipid or polymer-based nanoparticles, delivery using carbon nanomaterials and so on, have been developed in an effort to protect the structural integrity of the bioactive molecule. [29][30][31] And these carriers showed high RSV loading capacity, enabling their use in biomedical applications. [32][33][34] In this study, a formulation based on poly(d,l-lactideco-glycolide) (PLGA) lipid nanoparticles (PNPs) that covalently conjugate ICG and folic acid (FA) -a tumor targeting molecule, 35,36 in addition to encapsulating RSV, has been prepared (FA-RSV/ICG-PLGA-lipid NPs, abbreviated as FA-RIPNPs) as a targeted NIR probe and RSV carrier for U87 glioma theranostic applications by using a facile self-assembly method (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Xin

Yang

2016

IJN

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“…23 Furthermore, the polymer of PSS can supply more 2D aromatic planes to rGO, thus significantly enhancing its drug loading efficiency. 24 Therefore, the PSS-decorated nanographene (PSSG) has attracted more and more attention recently. [25][26][27] However, almost all of those works concentrated on the capacitance performance, the electrochemical, and dielectric properties of PSS-functionalized rGO, 28 but less attention has been paid to the biological applications of PSSG, especially in the field of drug carrier development.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the obtained PSSG has a high drug-loading capacity through π-π stacking. 24,35 XRD patterns of the prepared PSSG were also performed to investigate the interlayer distance between the nanosheets and the deoxygenation process of GO. 41 In Figure 3D, the strong peak at 2θ =26.6° of graphite (curve b) and the weak peak at 2θ =11.1° of GO (curve a) indicate an increasing distance between the interlayers of GO, which is due to the existence of water molecules and oxygenous groups in the spacing of graphene sheets.…”

mentioning

confidence: 99%

Preparation and tumor cell model based biobehavioral evaluation of the nanocarrier system using partially reduced graphene oxide functionalized by surfactant

Wang

Liu²,

Luo

2015

IJN

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Background Currently, surfactant-functionalized nanomaterials are tending toward development of novel tumor-targeted drug carriers to overcome multidrug resistance in cancer therapy. Now, investigating the biocompatibility and uptake mechanism of specific drug delivery systems is a growing trend, but usually a troublesome issue, in simple pharmaceutical research. Methods We first reported the partially reduced graphene oxide modified with poly(sodium 4-styrenesulfonate) (PSS) as a nanocarrier system. Then, the nanocarrier was characterized by atomic force microscope, scanning electron microscope, high-resolution transmission electron microscope, ultraviolet–visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy, X-Ray powder diffraction, and Raman spectroscopy. Epirubicin (EPI) was attached to PSSG via π–π stacking, hydrogen bonding, and physical absorption to form conjugates of PSSG–EPI. The adsorption and desorption profiles, cytotoxicity coupled with drug accumulation, and uptake of PSSG and PSSG–EPI were evaluated. Finally, the subcellular behaviors, distribution, and biological fate of the drug delivery system were explored by confocal laser scanning microscope using direct fluorescence colocalization imaging and transmission electron microscopy. Results The partially reduced graphene oxide sheets functionalized by surfactant exhibit good dispersibility. Moreover, due to much less carboxyl groups retained on the edge of PSSG sheets, the nanocarriers exhibit biocompatibility in vitro. The obtained PSSG shows a high drug-loading capacity of 2.22 mg/mg. The complexes of PSSG–EPI can be transferred to lysosomes in 2 hours through endocytosis, then the drug is released in the cytoplasm in 8 hours, and ultimately EPI is delivered into cell nucleus to exhibit medicinal effects in 1 day. Conclusion The comprehensive exploration of the biological uptake mechanism of functional graphene-mediated tumor cell targeting model provides a typical protocol for evaluation of drug delivery system and will benefit the discovery of new surfactant-modified nanocarriers in nanomedicine.

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One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery

Cited by 173 publications

References 41 publications

Graphene-Based Nanomaterials for Theranostic Applications

Graphene-Based Nanomaterials for Theranostic Applications

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Preparation and tumor cell model based biobehavioral evaluation of the nanocarrier system using partially reduced graphene oxide functionalized by surfactant

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