precise tailoring of electromagnetic waves through arbitrary control of the phase, [2] amplitude, [3] and polarization. [4] Such properties have been exploited in promising potentials to miniaturize devices in various optical applications such as computergenerated holography, [5,6] imaging, [7,8] and optical communications. [9][10][11] In particular, the versatility of metasurface-generated holography for recreating dynamic images has attracted tremendous interest for various applications in virtual and augmented reality, [12,13] optical data storage, [14] and security. [15][16][17] So far, metasurface-generated holography has been actively reported for high efficiency, [6,18] multicolor, [19,20] and three-dimensional (3D) holography. [21,22] For these promising practical applications, the ultimate goal is to increase data capacities by using multifunctional metasurfaces with independent holographic information channels for various physical properties of light, including polarization, [23] wavelength, [19] and orbital angular momentum. [24,25] The most general approach to design multifunctional metasurfaces is based on physical intuition to circumvent the information capacity limitations of single metasurfaces. These intuition-guided design methods include either using spatial multiplexing schemes [19,20,26] or engineering the meta-atom response to light with different properties. [27][28][29] The first approach exploits Metasurface-generated holography has emerged as a promising route for fully reproducing vivid scenes by manipulating the optical properties of light using ultra-compact devices. However, achieving multiple holographic images using a single metasurface is still difficult due to the capacity limit of a single meta-atom. In this work, an inverse design method based on gradient-descent optimization is presented to encode multiple pieces of holographic information into a single metasurface. The proposed method allows the inverse design of single-cell metasurfaces without the need for complex meta-atom design strategies, facilitating high-throughput fabrication using broadband low-loss materials. By exploiting the proposed design method, both multiplane red-green-blue (RGB) color and three-dimensional (3D) holograms are designed and experimentally demonstrated. Multiplane RGB color holograms with nine distinct holograms are achieved, which demonstrate the state-of-the-art data capacity of a phase-only metasurface. The first experimental demonstration of metasurface-generated 3D holograms with completely independent and distinct images in each plane is also presented. The current research findings provide a viable route for practical metasurface-generated holography by demonstrating the high-density holography produced by a single metasurface. It is expected to ultimately lead to optical storage, display, and full-color imaging applications.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202208520.