One‐step polymerization of hydrophilic ionic liquid imprinted polymer in water for selective separation and detection of levofloxacin from environmental matrices

Abstract

A novel green hydrophilic levofloxacin imprinted polymer was presented via onestep polymerization in water using ionic liquid 1,6-hexa-3,3 ′ -bis-1-vinylimidazolium bromine with multiple hydrophilic groups and 2-hydroxyethyl methacrylate as a cofunctional monomer. Adsorption experiment revealed that the ionic liquid significantly improved the water compatible of imprinted polymer, and the excellent recognition of molecularly imprinted polymer for levofloxacin in water corresponds to the synergetic effect of H-bonding and the electrostatic and π-π interactions between the levofloxacin and co-functional monomer. Furthermore, the adsorption process of the imprinted material towards levofloxacin fitted the Langmuir model, and the maximum binding amount of levofloxacin onto the imprinted and corresponding non-imprinted polymer were 16.45 and 6.82 mg/g at 25 • C, respectively. After optimizing the parameters affecting solid phase extraction performance, an enrichment and determination system was achieved to separate and detect levofloxacin from water and sediment samples with recoveries that ranged from 83.67 to 101.33% and relative standard deviation of less than 5.59%. K E Y W O R D Sionic liquids, levofloxacin, molecularly imprinted polymers, water

Recent advances and applications of molecularly imprinted polymers in solid‐phase extraction for real sample analysis

“…In addition, ionic liquids can also be used as new hydrophilic monomers for preparing another kind of hydrophilic MIPs (IL‐MIPs) [55–57]. For example, Zhu et al.…”

“…For example, Zhu et al. [56] synthesized an IL‐MIP‐coated PSD adsorbent in aqueous environment, using 1,6‐hexa−3,3′‐bis−1‐vinylimidazolium bromide (a hydrophilic ionic liquid) and 2‐hydroxyethyl methacrylate as functional monomers, for selective MISPE of levofloxacin from environmental waters and sediment, where the synergetic effect of hydrogen bond and electrostatic and π‐π interactions was the primary driving force for adsorption. The hydrophilic IL‐MIPs can be synthesized in water and finally applied to the MISPE of analytes in aqueous solutions.…”

“…In addition, the MIP particles synthesized via various surface imprinting techniques, such as surface grafting and coating on substrates, can present fast binding kinetics to target analytes due to the binding sites at/close to the adsorbent surface and consequently also utilized for MISPE [55,56,77–79]. A kind of water compatible ionic‐liquid‐based MIP‐grafted PSD microspheres (Figure 7C) was prepared in water by Zhu et al.…”

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

“…Recent work has expanded their application to include molecular recognition in aqueous solutions, which is a positive progress towards their implementation in real‐world application. [ 197 ]…”

“…Recent work has expanded their application to include molecular recognition in aqueous solutions, which is a positive progress towards their implementation in real-world application. [197] MIPs are prepared by first synthesizing the monomer, and subsequently copolymerizing. The monomer is synthesized in the presence of the template (i.e., the desired analyte), which is subsequently solvent washed to leave behind an imprint.…”