One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection

Dou, Shuzhen; Wang, Zhongshun; Chen, Qiye; Lü, Nan

doi:10.1016/j.snb.2022.131578

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…The TSi substrate was prepared by mask-less reactive ion etching. 20 The cleaned silicon slide was directly controlled using a Plasmalab Oxfold 80 plus (ICP65) system (Oxford Instrument Co., UK) with the parameters as follows: the gas flows of SF 6 /CHF 3 /O 2 were 40/10/40 sccm/sccm/sccm; the set pressure was 30 mTorr; the radio frequency power was 100 W. After the etching process, the sample was immersed in 0.04 vol% HF for 20 min to remove the oxide layer on the silicon surface. Finally, the TSi substrate was taken out of the Paper PCCP solution, rinsed with deionized water, and subjected to N 2 purging.…”

Section: Fabrication Of the Tsi Substratementioning

confidence: 99%

Laser desorption/ionization on nanostructured silicon: morphology matters

Dou

Wang

et al. 2022

Phys. Chem. Chem. Phys.

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Section: Fabrication Of the Tsi Substratementioning

confidence: 99%

Laser desorption/ionization on nanostructured silicon: morphology matters

Dou

Wang

et al. 2022

Phys. Chem. Chem. Phys.

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“…As alternatives to traditional matrixes, researchers have proposed metal/metal oxide-based ( Sakurai et al., 2018 ; Sagandykova et al., 2022 ), carbon-based ( Xu et al., 2021 ), and silicon-based ( Dou et al., 2022 ) matrixes. Metal particles with nanoscale diameters are of interest due to their unique plasmon absorption in the visible region, in which gold nanoparticles (Au NP) and silver nanoparticles (Ag NP) are the often utilized metal matrixes.…”

Section: Introductionmentioning

confidence: 99%

Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues

et al. 2023

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Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can visualize the spatial distribution characteristics of molecules in tissues in situ, in which the matrix plays a key role. In this paper, we propose a platinum nanomaterial pre-coated matrix, which can be prepared in bulk by sputtering platinum nanoparticles onto slides using an ion sputterer and then used for MALDI-MS analysis by placing tissue sections on the matrix. We used this matrix for MALDI-MS imaging analysis of corn kernels and germinated wheat sections, and the results show that triacylglycerides were mainly distributed in the embryo of corn kernels and germinated wheat, and sugars were mainly distributed in the endosperm, with the highest content of disaccharides.It provides a simple and reliable experimental condition for analyzing the distribution of oligosaccharide and lipid components in plant tissues.

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“…Over the last few years, many different types of surfaces have been developed for use in SALDI MS. These surfaces were developed based on nanoparticles of metals [14], metal oxides [15], carbon [3] and silicon [16].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Layer of Silver for Detection of Small Biomolecules in Surface-Assisted Laser Desorption Ionization Mass Spectrometry

et al. 2022

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A facile approach for the synthesis of a silver nanostructured layer for application in surface-assisted laser desorption/ionization mass spectrometry of low-molecular-weight biomolecules was developed using electrochemical deposition. The deposition was carried out using the following silver salts: trifluoroacetate, acetate and nitrate, varying the voltage and time. The plate based on trifluoroacetate at 10 V for 15 min showed intense SALDI-MS responses for standards of various classes of compounds: fatty acids, cyclitols, saccharides and lipids at a concentration of 1 nmol/spot, with values of the signal-to-noise ratio ≥50. The values of the limit of detection were 0.71 µM for adonitol, 2.08 µM for glucose and 0.39 µM for palmitic acid per spot. SEM analysis of the plate showed anisotropic flower-like microstructures with nanostructures on their surface. The reduced chemical background in the low-mass region can probably be explained by the absence of stabilizers and reducing agents during the synthesis. The plate synthesized with the developed approach showed potential for future use in the analysis of low-molecular-weight compounds of biological relevance. The absence of the need for the utilization of sophisticated equipment and the synthesis time (10 min) may benefit large-scale applications of the layer for the detection of various types of small biomolecules.

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One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection

Cited by 3 publications

References 40 publications

Laser desorption/ionization on nanostructured silicon: morphology matters

Laser desorption/ionization on nanostructured silicon: morphology matters

Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues

Nanostructured Layer of Silver for Detection of Small Biomolecules in Surface-Assisted Laser Desorption Ionization Mass Spectrometry

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