One-step fabrication of biocompatible carboxymethyl cellulose polymeric particles for drug delivery systems

Bütün, Sultan; Ince, Fatma Gul; Erduğan, Hüseyin; Şahiner, Nurettin

doi:10.1016/j.carbpol.2011.05.001

Cited by 116 publications

(47 citation statements)

References 24 publications

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“…Chemical-crosslinking provides CMC gels a more stable three-dimensional network. For example, divinyl sulfone [14], epichlorohydrin [15], aldehydes [16,17], fumaric acid [18] and citric acid [19] have been used as crosslinkers to form CMC and CMC composite gels. Monomers with double bond, such as N-isopropyl acrylamide [20] and partially neutralized acrylic acid/rectorite [21], have been initiated by ammonium persulfate and coupled onto CMC backbones via methylene bisacrylamide (crosslinker).…”

Section: Introductionmentioning

confidence: 99%

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

Ke¹,

Liu²,

Wang

et al. 2014

Express Polym. Lett.

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Abstract. Biocompatible and biodegradable carboxymethyl cellulose (CMC) has been modified with 4-hydroxybenzylamine (CMC-Ph) in order to prepare CMC-based microgels through the horseradish peroxidise/hydrogen peroxide enzymatic reaction. CMC-Ph was identified as a blend, and the amount of the grafted 4-hydroxybenzylamine per 100 units of CMC was between 17 and 23 according to the molecular weight of CMC. Through a special designed co-flowing microfluidic device, CMC-Ph microgels were prepared with the radius from 100 to 500 µm via adjusting the flow rates of the disperse phase and the continuous phase, respectively. The chondrocytic cell line ATDC5 was encapsulated in the CMC-Ph microgels. The cell-laden microgels were cultured for up to 40 days, illustrating the biocompatibility of CMC-Ph and the microfluidic approach through the enzymatic crosslinking reaction primarily. CMC-Ph showed a great promise to encapsulate the cells for further fabrication of the injectable scaffolds.

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Section: Introductionmentioning

confidence: 99%

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

Ke¹,

Liu²,

Wang

et al. 2014

Express Polym. Lett.

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“…Porém, cápsulas de alginato normalmente apresentam poros, o que permite a difusão da temperatura para o interior da cápsula (Mandal et al, 2006;Ding & Shah, 2009;Gouin, 2004). Outros materiais que podem ser utilizados na encapsulação de probióticos, como o carboximetilcelulose também apresentam o problema de gerar cápsulas porosas (Butun et al, 2011). Como alternativa, outros materiais de cápsulas podem ser incluídos como quitosana, trehalose, inulina, leite em pó, maltodextrina, farelo de arroz, entre outros para aumentar a proteção aos probióticos (Cavalheiro et al, 2015;Silva et al, 2015;Chitprasert et al, 2012).…”

Section: Emulsificaçãounclassified

Encapsulação: alternativa para a aplicação de microrganismos probióticos em alimentos termicamente processados

Cavalheiro

Etchepare

Menezes³

et al. 2015

CeN

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“…In its chain structure, it presents a high number of hydroxyl groups suitable to be converted, by chemical modification, into cellulose esters [52]. These cellulose derivatives are more suitable to be applied in different areas, such as enteric coatings, hydrophobic matrices, and semi-permeable membranes for applications in pharmaceuticals, agriculture, and cosmetics [52][53][54]. Furthermore, the cellulose esters can be applied in the field of controlled release systems, due to their well established preparation processes, application safety and good handling properties [55].…”

Section: Cellulose Derivativesmentioning

confidence: 99%