One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes

Die Renaissance des H/D‐Austausches

“…Der homogen katalysierte H/D-Austausch mit Platin beschränkt sich seit den Pionierarbeiten von Garnett [48a-b, 66] und Shilov [49a-b] mit wenigen Ausnahmen [67] auf Tetrachloridopla- [74] Schema 24. Mikrowellen-unterstützter, homogen katalysierter H/DAustausch mit Platin nach Jones et al [28] Schema 25.…”

“…Mit diesem Katalysator konnten benzylische Wasserstoffatome bei Raumtemperatur innerhalb Schema 29. Deuterierung von 4-Benzylpiperidin (88) nach Lockley et al [74] Schema 30. Assoziativer (I) und dissoziativer Mechanismus (II) des heterogenen H/D-Austausches aromatischer Substrate.…”

Preparation of Tritium‐Labeled Compounds by Isotope Exchange Reactions

“…A recent report 170 describes an exploration of several catalysts and substrates with 2 H 2 O as the isotope source at 150 C for 3 h in DMSO or DMF cosolvent. Complexes found to be most active were the already-studied Ru(PPh 3 ) 3 Cl 2 and the new complexes [Ru(p-cymene) 3 Cl 2 ] 2 , [Ru(h 6 -benzene) 2 Cl 2 ] 2 and, most active, [Ru(CO) 3 Cl 2 ] 2 .…”

Tritium chemistry: history, current status and future developments; a brief review

“…21b,c In addition, the convenience of modern automated microwave systems 23 promises to revolutionize radiochemical preparations and speed up the search for new labelling catalysts. 17b, 24 An interesting area with potential applications in tritium chemistry is that of microreactors, 25a,b though these have so far only been applied to deuterium and b + emitters.…”