One‐Step Electrodeposition of Multi‐element Doped Hydroxyapatite Nanocoating Leading to Enhanced Cytocompatible and Antibacterial Properties of Titanium Implants

Abstract

The introduction of trace elements into hydroxyapatite (HA) coatings has been widely used for antimicrobial and biocompatible modification of metal implants. In this study, a multifunctional coating of HA co-doped with Cu 2 + , Zn 2 + , Sr 2 + and F À (CuZnSrFHA) was synthesized on titanium substrate by onestep electrodeposition technology. The CuZnSrFHA consisted of nanoscale needle-like crystals with low roughness and poor hydrophilicity. However, it can continuously release Cu 2 + , Zn 2 + and Sr 2 + within 14 days while maintaining good physiological stability. Based on the synergistic effect of Cu and Zn, the CuZnSrFHA coating showed some inhibitory effect on E. coli and S. aureus. Furthermore, the CuZnSrFHA was not significantly cytotoxic and promoted early adhesion and alkaline phosphatase activity of osteoblasts. In conclusion, the multielement co-doped CuZnSrFHA coating was expected to be a novel surface modification material for the prevention of infectious bone defects.

Corrosion Prevention of Biomedical Implants: Surface Coating Techniques Perspective

“…Various metal groups have been studied including NiÀ P, NiÀ PÀ W, Ag/Pd, NiÀ P/Sn, Cu/Ag, etc. [61][62][63][64][65][66] These studies show that electrodeposited coatings greatly improve the corrosion properties of the substrate. Two processes under this type of coating are -Electrolytic deposition and Electrophoretic deposition.…”

“…Alternatively, it is a metal deposition process in which metal cations from the solution are deposited on the surface of the substrate connected to the cathode by the passage of an electric current. Various metal groups have been studied including Ni−P, Ni−P−W, Ag/Pd, Ni−P/Sn, Cu/Ag, etc [61–66] . These studies show that electrodeposited coatings greatly improve the corrosion properties of the substrate.…”