One-step detection of alpha fetal protein based on gold microelectrode through square wave voltammetry

Zhai, Jiali; Ying, Jia; Ji, Piyou; Wang, Feifan; Zhang, Xiaoqing; Zhao, Guangtao

doi:10.1016/j.ab.2022.114916

Cited by 4 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sensor demonstrated an LOD of 0.01 ng/mL and exhibited a linear detection range of 0.4 to 1000 ng/mL. In another study, Zhai et al engineered an alpha-fetoprotein (AFP) sensor utilizing a gold microelectrode denoted as AuµE [68]. The sensor employed square wave voltammetry with [Fe(CN) 6 ] 3−/4− as a mediator.…”

Section: Electrochemical Aptasensor-based Detection Of Alpha-fetoproteinmentioning

confidence: 99%

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

Ramachandran,

Abul Rub,

Hajja

et al. 2024

Biosensors

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is currently one of the most prevalent cancers worldwide. Associated risk factors include, but are not limited to, cirrhosis and underlying liver diseases, including chronic hepatitis B or C infections, excessive alcohol consumption, nonalcoholic fatty liver disease (NAFLD), and exposure to chemical carcinogens. It is crucial to detect this disease early on before it metastasizes to adjoining parts of the body, worsening the prognosis. Serum biomarkers have proven to be a more accurate diagnostic tool compared to imaging. Among various markers such as nucleic acids, circulating genetic material, proteins, enzymes, and other metabolites, alpha-fetoprotein (AFP) is a protein marker primarily used to diagnose HCC. However, current methods need a large sample and carry a high cost, among other challenges, which can be improved using biosensing technology. Early and accurate detection of AFP can prevent severe progression of the disease and ensure better management of HCC patients. This review sheds light on HCC development in the human body. Afterward, we outline various types of biosensors (optical, electrochemical, and mass-based), as well as the most relevant studies of biosensing modalities for non-invasive monitoring of AFP. The review also explains these sensing platforms, detection substrates, surface modification agents, and fluorescent probes used to develop such biosensors. Finally, the challenges and future trends in routine clinical analysis are discussed to motivate further developments.

show abstract

Section: Electrochemical Aptasensor-based Detection Of Alpha-fetoproteinmentioning

confidence: 99%

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

Ramachandran,

Abul Rub,

Hajja

et al. 2024

Biosensors

View full text Add to dashboard Cite

show abstract

A comparative analysis of square-wave voltammetry and multi-frequency electrochemical Faradaic spectroscopy for kinetic characterisation

Glaubitz,

Mirceski,

Schröder

2024

J Solid State Electrochem

View full text Add to dashboard Cite

A rigorous comparison between square-wave voltammetry (SWV) and the recently proposed multi-frequency electrochemical Faradaic spectroscopy (MEFS) is presented for both a quasireversible electrode reaction of a dissolved redox couple at a planar macroscopic electrode and a catalytic regenerative electrode mechanism (EC′ reaction scheme) by means of numerical simulations. MEFS offers fast kinetic characterisation with a minimal set of experiments, as the system is interrogated with a range of SW frequencies in a single experiment. By changing the mid-potential Em, a critical parameter of MEFS, a broad range of standard rate constants for the heterogeneous interfacial electron transfer is accessible, ranging between 0.006 and 0.12 cm s−1. In the case of the EC′ mechanism, features of the current components in both SWV and MEFS reflect the involvement of the follow-up regenerative chemical reaction (i.e. C′ catalytic step). However, for the kinetic characterisation of the EC′ mechanism, the comparative analysis suggests that SWV should be the main operating technique.

show abstract

Electrochemical behavior of Newcastle virus La Sota strain (Newvac vaccine) in the presence of gold nanoparticles as sensitizers investigated on Au electrode

Tutunaru

2024

International Journal of Electrochemical Science

View full text Add to dashboard Cite

One-step detection of alpha fetal protein based on gold microelectrode through square wave voltammetry

Cited by 4 publications

References 32 publications

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

A comparative analysis of square-wave voltammetry and multi-frequency electrochemical Faradaic spectroscopy for kinetic characterisation

Electrochemical behavior of Newcastle virus La Sota strain (Newvac vaccine) in the presence of gold nanoparticles as sensitizers investigated on Au electrode

Contact Info

Product

Resources

About