One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

Şenışık, Ahmet Murat; İçhedef, Çiğdem; Kılçar, Ayfer Yurt; Uçar, Eser; Ari, Kadir; Göksoy, Didem; Parlak, Yasemın; Bilgin, Bedriye Elvan Sayıt; Teksöz, Serap

doi:10.1007/s10967-018-5772-x

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…The very simple procedure for using clinically readily available FDG for ligation with peptides was demonstrated using the small peptide glycylglycine as an example [73]. Starting from the commercially available [ 18 F]FDG solution and after cleavage of the BOC protecting group from the aminooxy-derivatized peptide, [ 18 F]FDG-GlyGly (60) could be obtained in a RCY of 98% at 100 • C after 30 min.…”

Section: [ 18 F]fdg For Chemoselective 18 F-fluoroglycosylation By Oxime Linkagementioning

confidence: 99%

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

2021

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In the field of 18F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been implemented, including chemoselective 18F-labeling of biomolecules. Among those, chemoselective 18F-fluoroglycosylation methods focus on the sweetening of pharmaceutical radiochemistry by offering a highly valuable tool for the synthesis of 18F-glycoconjugates with suitable in vivo properties for PET imaging studies. A previous review covered the various 18F-fluoroglycosylation methods that were developed and applied as of 2014 (Maschauer and Prante, BioMed. Res. Int. 2014, 214748). This paper is an updated review, providing the recent progress in 18F-fluoroglycosylation reactions and the preclinical application of 18F-glycoconjugates, including small molecules, peptides, and high-molecular-weight proteins.

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Section: [ 18 F]fdg For Chemoselective 18 F-fluoroglycosylation By Oxime Linkagementioning

confidence: 99%

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

2021

View full text Add to dashboard Cite

show abstract

“…The very simple procedure for using clinically readily available FDG for ligation with peptides was demonstrated using the small peptide glycylglycine as an example [74]. Starting from the commercially available [ 18 F]FDG solution and after cleavage of the BOC protecting group from the aminooxy-derivatized peptide, [ 18 F]FDG-GlyGly (60) could be obtained in a RCY of 98% at 100°C after 30 min.…”

Section: [ 18 F]fdg For Chemoselective 18 F-fluoroglycosylation By Oxime Linkagementioning

confidence: 99%

Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects

Shinde¹,

Maschauer²,

Prante³

2021

Preprint

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In the field of 18F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been im-plemented, including chemoselective 18F-labeling of biomolecules. Among those, chemoselec-tive 18F-fluoroglycosylation methods focus on the sweetening of pharmaceutical radiochemistry by offering a highly valuable tool for the synthesis of 18F-glycoconjugates with suitable in vivo properties for PET imaging studies. A previous review covered the various 18F-fluoroglycosylation methods that have been developed and applied as of 2014 [Maschauer and Prante, BioMed. Res. Int. 2014, 214748]. This paper is an updated review, providing the recent progress in 18F-fluoroglycosylation reactions and the preclinical application of 18F-glycoconjugates, including small molecules, peptides, and high-molecular-weight proteins.

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Promising potential of a 18F-labelled small-molecular radiotracer to evaluate PD-L1 expression in tumors by PET imaging

Miao

Chen

et al. 2021

Bioorganic Chemistry

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One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

Cited by 8 publications

References 17 publications

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

Sweetening Pharmaceutical Radiochemistry by <sup>18</sup>F-Fluoroglycosylation: Recent Progress and Future Prospects

Promising potential of a 18F-labelled small-molecular radiotracer to evaluate PD-L1 expression in tumors by PET imaging

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