One step closer to a global tool for rapid screening of major depression in epilepsy: Validation of the French NDDI-E

Micoulaud-Franchi, Jean-Arthur; Barkate, Gérald; Fonseca, Agnès Trébuchon-Da; Vaugier, Lisa; Gavaret, Martine; Bartolomei, Fabricē; McGonigal, Aileen

doi:10.1016/j.yebeh.2014.12.011

Cited by 54 publications

(34 citation statements)

References 32 publications

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“…The study sample includes 380 patients with epilepsy collected in three studies in Italy, Germany, and France (Table ). In all studies, patients were consecutively recruited and assessed with the same clinical instruments, namely the Mini International Neuropsychiatric Interview (MINI) v. 5.0.0 and the NDDIE .…”

Section: Methodsmentioning

confidence: 99%

Validation of rapid suicidality screening in epilepsy using the NDDIE

et al. 2016

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SUMMARYObjective: Standard mortality ratio for suicide in patients with epilepsy is three times higher than in the general population, and such a risk remains high even after adjusting for clinical and socioeconomic factors. It is thus important to have suitable screening instruments and to implement care pathways for suicide prevention in every epilepsy center. The aim of this study is to validate the use of the Neurological Disorder Depression Inventory for Epilepsy (NDDIE) as a suicidality-screening instrument. Methods: The study sample included adult patients with epilepsy assessed with the Mini International Neuropsychiatric Interview (MINI) and the NDDIE. A high suicidality risk according to the Suicidality Module of the MINI was considered the gold standard. Receiver operating characteristic analyses for NDDIE total and individual item scores were computed and subsequently compared using a nonparametric approach. The best possible cutoff was identified with the highest Youden index (J). Likelihood ratios were then computed, and specificity, sensitivity, positive, and negative predictive values calculated. Results: The study sample consisted of 380 adult patients with epilepsy: 46.3% male; mean age was 39.4 AE 14.6; 76.7% had a diagnosis of focal epilepsy; mean age at onset of the epilepsy was 23.3 AE 17.5. According to the MINI, 74 patients (19.5%) fulfilled criteria for a major depressive episode and 19 (5%) presented a high suicidality risk. A score >2 (J = 0.751) for item 4 "I'd be better off dead" of the NDDIE displayed excellent psychometric properties with a good to excellent validity (area under the curve [AUC] 0.906; 95% confidence interval [CI] 0.820-0.992; p < 0.001), sensitivity 84.21% (95% CI 60.4-96.6), specificity 90.86% (95% CI 87.4-93.6), likelihood ratio+ 9.21 (95% CI 6.3-13.5), likelihood ratio-0.17 (95% CI 0.06-0.50). Significance: Item 4 of the NDDIE has shown to be an excellent suicidality screening instrument allowing the development of further care pathways for suicide prevention in epilepsy centers.

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Section: Methodsmentioning

confidence: 99%

Validation of rapid suicidality screening in epilepsy using the NDDIE

et al. 2016

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“…The MINI was designed to screen for psychiatric diagnoses in research and clinical settings. It is widely used in epilepsy settings and has been validated against gold standard diagnostic interviews, such as the Structured Clinical Interview for DSM-V. 13,14,34 For the present study, the anxiety disorders and depressive disorders modules were administered. The epilepsy addendum to the MINI developed by Mintzer and Lopez 35 was also administered.…”

Section: Validity and Reliability Of Both Easi And Breasimentioning

confidence: 99%

“…The development of the NDDI‐E was conducted considering the shared features of depression and epilepsy that threaten the accuracy of generic screening measures . It has been recognized internationally as a useful and time‐efficient screening tool (taking 1 to 3 minutes to administer), and its diagnostic accuracy has been replicated in later studies . Since its development in 2006, it has been translated for use in >12 languages, and for use in both adult and pediatric populations …”

Section: Introductionmentioning

confidence: 99%

Design and validation of two measures to detect anxiety disorders in epilepsy: The Epilepsy Anxiety Survey Instrument and its brief counterpart

et al. 2019

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Objective The study objective was to develop and validate the first epilepsy‐specific anxiety survey instrument (Epilepsy Anxiety Survey Instrument [EASI]) alongside a briefer screening instrument to detect anxiety disorders in routine clinical practice (brEASI). Methods The instruments were developed utilizing a mixed‐methods approach in four related studies. Pilot items were developed following qualitative interviews with people with epilepsy (PWE; Study 1) and consultation with multidisciplinary experts in anxiety and epilepsy (Study 2). PWE (n = 314) then completed pilot items alongside existing measures of anxiety and depression (Study 3). Factor analysis was conducted to refine the scale and select well‐performing items for a briefer diagnostic screener (brEASI). The brEASI was validated against a gold standard diagnostic interview in 106 PWE recruited from an outpatient epilepsy service (Study 4). Receiver operating characteristic analysis was conducted to determine the brEASI‘s diagnostic performance. Results Twenty‐six pilot items were generated based on the findings of Studies 1 and 2. Analyses in Study 3 resulted in an 18‐item EASI, and eight well‐performing items were selected for the brEASI. The area under the curve (AUC) of brEASI was excellent (AUC = 0.89, 95% confidence interval = 0.82‐0.94). At a cutoff of 7, it demonstrated a sensitivity of 76% and specificity of 84% for identifying Diagnostic and Statistical Manual of Mental Disorders, 5th edition anxiety disorders. Significance The EASI and brEASI represent the first valid and reliable epilepsy‐specific anxiety instruments. The EASI has been designed to comprehensively assess anxiety in PWE, whereas the brEASI may be used within busy neurology settings to provide rapid information to aid diagnoses of anxiety disorders. Given the significant prevalence and burden of anxiety in PWE, these tools are important potential solutions to improve the understanding and detection of anxiety in epilepsy.

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“…3 Appropriate screening tools are crucial given the symptomatic overlap with the effects of antiepileptic drugs; this diagnostic challenge led to the development of the NDDI-E for adults with epilepsy, 4 a 6-item questionnaire with robust psychometric properties across languages and populations. 5 The NDDI-E was thus a logical basis for the 12-item NDDI-E-Y that aims at screening for MDD in 12-to 17-year-olds. 1 We wished to validate this instrument in a group of 98 French patients using standard methodology, 6 following our previous experience of validating screening instruments in French 5, 7-9 and using methodology equivalent to that of Wagner et al, 1 comparing NDDI-E-Y scores to the Children's Depression Inventory (CDI).…”

Section: Screening For Depression In Youth With Epilepsy: the Nddi-e-ymentioning

confidence: 99%